I-Yucca schidigera, isitshalo sasogwadule esidabuka eningizimu-ntshonalanga ye-United States naseMexico, ithole ukunakwa okubalulekile embonini yezemithi, ezomsoco, nezimonyo ngenxa yezinhlanganisela zayo ze-bioactive, ikakhulukazi ama-saponins nama-polyphenols. Lesi sihloko sihlola i-antioxidant kanye{1}izindlela zokulwa nokuvuvukala ze-Yucca extract, esekelwa ucwaningo lwamazwe ngamazwe, futhi igqamisa izinzuzo zayo eziyingqayizivele kunezinye izitshalo{2}}ezikhishiwe.
Izingxenye Ezibalulekile Ze-Bioactive
Ukukhishwa kwe-Yucca schidigerainothile ngama-saponins e-steroidal (isb, i-sarasapogenin, i-markogenin) nama-polyphenols (isb., ama-analogues e-resveratrol, ama-yuccaols). Lezi zinhlanganisela ziyisisekelo samandla awo okwelapha:
Ama-Saponins: Aziwa ngesakhiwo sawo se-amphiphilic, ama-saponins aguqula ukufinyeleleka kwe-membrane yeselula futhi abonise umsebenzi oqinile wokuqothula ama-radical mahhala (Cheeke et al., 2006).
Ama-Polyphenols: Ama-Yuccaol akhombisa amandla aphezulu e-antioxidant uma kuqhathaniswa nama-polyphenol avamile afana nalawo asetiyeni eliluhlaza, ngenxa yamaphethini awo ayingqayizivele e-hydroxylation (Piacente et al., 2004).
Umsebenzi we-Antioxidant
Ukukhishwa kwe-Yucca kunciphisa izinhlobo ze-oxygen esebenzayo (ROS) futhi kunciphisa ukucindezelwa kwe-oxidative, okunomthelela omkhulu ekugugeni, ukuvuvukala, kanye nezifo ezingapheli.
Izifundo ze-in vitro: I-Yucca polyphenols ibonise umsebenzi wokulahla i-ROS ophindwe izikhathi ezingu-2.3 kune-ascorbic acid ekuhlolweni kwe-DPPH (Marzocco et al., 2015).
Ukuqinisekiswa kwe-vivo: Ucwaningo lwango-2020 ku-Journal of Ethnopharmacology lubike ukuthi i-Yucca saponins yehlise i-lipid peroxidation ngo-40% kumamodeli wamagundane omonakalo we-hepatic oxidative, i-milk thistle extract (Singh et al., 2020).
Uma ufuna ukuthola umphakeli onokwethenjelwa we-Yucca ekhishwe e-China, kulungile ukukhetha i-Wellgreen. I-Wellgreen ingumkhiqizi okhipha izitshalo ochwepheshe onesitifiketi se-EU FAMI-i-QS nesitifiketi se-GRAS. Lezi ziqu ziqinisekisa ikhwalithi nokuphepha kwe-Yucca ekhishwe, okuyenza isetshenziswe kabanzi kuzimonyo, ukudla kwezilwane, kanye nokusetshenziswa kwabantu. Sicela uthumele i-imeyili ukuze uthole uphenyo. I-ID ye-imeyili: liu@wellgreenxa.com
Izindlela zokulwa nokuvuvukala
I-Yucca compounds ivimbela izindlela zokuvuvukala ngezinhloso eziningi:
Ukucindezelwa kwe-COX2 ne-TNF: I-Yucca saponins yehlise ukusho kwe-COX2 ngo-58% kumaseli e-macrophage womuntu, idlula ukusebenza kahle kwe-curcumin (ukunciphisa ngama-35%) ekuhlolweni okufanayo (Li et al., 2018).
Ukushintsha indlela ye-NFκB: I-Yuccaols ivimbe ukusebenzisa i-NFκB ngo-70% ku-50 ug/mL, uma kuqhathaniswa ne-quercetin kodwa ngemiphumela{2}}ehlala isikhathi eside (Piacente et al., 2004).
Izinzuzo Zokuncintisana Ngaphezu Kokunye Kwezitshalo
|
Khipha |
Umkhawulo Obalulekile |
Izinzuzo ze-Yucca Extract |
|
I-Aloe vera |
I-bioavailability ephansi yama-polysaccharides |
I-solubility ephakeme ye-saponin nokuzinza |
|
Itiye elihlaza |
Amakhathekhini awohloka ngokushesha ngaphansi kokushisa |
I-Yucca polyphenols imelana nokuwohloka kokushisa |
|
I-Turmeric |
Ukumuncwa okungalungile ngaphandle kwezithuthukisi |
Ukuzikhandla{0}}ama-saponins athuthukisa ukutholakala kwe-bioavailability |
Imithelela Yezempilo Nezohwebo
Ukunakekelwa Kwesikhumba: Izingcaphuno ze-Yucca zihlanganiswa kuma-serum avimbela ukuguga ngenxa yemiphumela yawo ekabili ye-antioxidant kanye ne-collagen-imiphumela yokuvikela (Koo et al., 2021).
Impilo yamathumbu: I-Yucca saponins inciphisa ukuvuvukala kwamathumbu kumamodeli we-IBS, ngokuthuthukiswa kwe-30% kwezimpawu ngokumelene ne-placebo (Journal of Functional Foods, 2019).
Isiphetho
Ukukhishwa kwe-Yucca schidigera kunikeza indlela eqinisekisiwe ngokwesayensi, enezinjongo eziningi ekucindezelekeni kwe-oxidative nokuvuvukala. Idlula amabhotanical amaningi ajwayelekile ngokuzinza, i-bioavailability, kanye nobubanzi bemishini. I-synergy yayo yama-saponins nama-polyphenols ikubeka njengesithako esilandelayo-sesizukulwaneni sokwakhiwa kwezempilo nokuphila kahle.
Izithenjwa
1. UCheeke, PR, et al. (2006). Ukubuyekezwa kwePhytochemistry, 5 (1), 27-33.
2. Piacente, S., et al. (2004). Ijenali Yemikhiqizo Yemvelo, 67(6), 882–885.
3. Singh, A., et al. (2020). Ijenali ye-Ethnopharmacology, 253, 112638.
4. Li, X., et al. (2018). I-International Immunopharmacology, 64, 110-118.
5. Koo, HJ, et al. (2021). Izimonyo, 8(3), 72.
Kuzinhlelo zokusebenza zemboni, izifundo ezengeziwe zokuqamba ziyanconywa ukuze kuthuthukiswe inhlanganisela ye-synergistic kanye nokusebenza okuhambisanayo (isb, i-hyaluronic acid yokunakekelwa kwesikhumba noma ama-probiotics nempilo yamathumbu).
