I-Liposomal Milk Thistle Stability, Storage & Global Regulatory Canations

Okwabaphathi bokuthengwa kwempahla, abaqondisi bokuqinisekisa ikhwalithi, kanye nokutholwa kososayensi bokwakhai-liposomal milk thistle powder, ukuqonda iphrofayela yokuzinza, izimfuneko zesitoreji, kanye nokuma kwezwe okulawula kubaluleke njengokuqinisekisa idatha ye-bioavailability. I-Silymarin{1}}i-bioactive flavonolignan complex evela ku-milk thistle (I-Silybum marianum){0}}icutshungulwe kabanzi ngenxa ye-antioxidant nesibindi-imisebenzi yebhayoloji ehlobene, kodwa izingcaphuno ezivamile zibhekana nezinselele ezingokwemvelo zokuzinza ezihlobene nokuzwela ukukhanya, i-oxidation, kanye nokuwohloka kokushisa. I-Liposomal silymarin isu elilodwa lokuqamba eliphenywayo ukuze kubhekwane nezinye zalezi zinselele nge-phospholipid{3}}i-encapsulation esekelwe, kuyilapho izinqubo zokomisa kanye nempushana{4}}zokuguqula zethula ukucatshangelwa kwekhwalithi okwengeziwe. Okokuthola izinkampaniinqwaba liposomal ubisi Thistle izithako, ukuqonda izici zokuzinza, izidingo zesitoreji, nokucatshangelwa kokulawula kubalulekile ngaphambi kokukhetha umphakeli.

 

 

 

Ukuqonda Ukuzinza kweSilymarin: Izinto Eziyinhloko Zokuwohloka

I-Silymarin kanye nezingxenye zayo ezinkulu ze-bioactive kusengozini yokuwohloka kusuka ezintweni ezimbalwa zemvelo:

• Ukukhanya: Ukuchayeka ekukhanyeni kungathinta ukuzinza kwezinye izingxenye ze-silymarin, ikakhulukazi ngaphansi kwezimo ezimanzi kanye nokuchayeka isikhathi eside kwe-UV. Ukuzwela kuyahlukahluka phakathi kwe-flavonolignans ngayinye futhi kufanele kuhlolwe ukwakheka okuqondile.
• I-oxidation: Ukuchayeka kumoya-mpilo kanye nezimo ze-oxidative kungaba nomthelela ekonakaleni. Izincwadi ezishicilelwe zihlonze i-2,3-dehydrosilybin njengomkhiqizo we-oxidation we-silybin.
• Ukushisa: Amazinga okushisa aphakeme angasheshisa ukuwohloka kwezakhi ze-silymarin, ikakhulukazi ngaphansi kokuchayeka isikhathi eside nasezindaweni ezithile ezinamanzi noma ezisebenzayo. Ukuzinza kwe-thermal kuwukwakheka- futhi kucutshungulwe{2}}kuncike, ngakho izinga lokushisa lokucubungula nokugcinwa kufanele lihlolwe kusetshenziswa idatha ethile yomkhiqizo{3}}yokuzinza.

Ukuzinza kungahluka kakhulu phakathi kokukhipha okomile kanye namalungiselelo ane-aqueous noma i-hydroalcoholic. Isibonelo, ucwaningo oluthile lubike impilo yeshelufu cishe yezinyanga ezintathu ku-25℃obisini{2}}izithako ezithakwayo zobisi.【7†L613-L624】 Lokhu okutholiwe akufanele kukhishwe ngokuqondile ku-extracts ezomile noma izimpushana ze-liposomal.

Ukuzinza kwe-Liposomal Silymarin Formulations

Qaphela:Amanani ashicilelwe aboniswe ngezansi avela ekwenziweni okukhethekile kwe-liposomal nezimo zocwaningo. Zinikezwa njengezibonelo zokusebenza okubikiwe, hhayi njengokucaciswa kwendawo yonke yezithako zethistle yobisi lwe-liposomal.

Ucwaningo lwezinhlamvu olushicilelwe lwe-silymarin ne-silibinin liposomes lubike le mingcele yokuzinza elandelayo:

Ipharamitha	I-Silymarin Liposomes	I-Silibinin Liposomes
Encapsulation Efficiency	92.05 ± 1.41%	87.86 ± 2.06%
Usayizi Wezinhlayiyana Zokuqala	3541.3 ± 62.5 nm	2074.7 ± 19.4 nm
Usayizi Wezinhlayiyana Ngemva kwezinsuku ezingu-28 ku-4 degree	2677.0 ± 44.2 nm	2704.0 ± 35.0 nm
I-PDI yokuqala	0.346 ± 0.044	0.328 ± 0.030
I-PDI Ngemuva kwezinsuku ezingama-28 ku-4 degree	0.228 ± 0.036	0.456 ± 0.026
Ukushintsha Okungenzeka Kwe-Zeta	-27.0 kuya ku-26.4 mV	-29.4 kuya ku-29.0 mV

Lokhu okutholakele kubonisa ukuthi ukwakheka kwe-liposomal okuhloliwe kugcine izici ze-physicochemical ezilinganisekayo ngaphansi kwezimo ezishiwo zokulondoloza nemisebe, kuyilapho kugqamisa ukwakheka{0}}imvelo encikile yokuqina kwe-liposome.【1†L5-L9】

Ucwaningo olushicilelwe lubonisa ukwakheka okukhulu-kuya-kokwenza umehluko ekuzinzeni kwe-liposomal, okubonisa ukuthi ukusebenza kwesitoreji akukwazi ukuchazwa egameni elithi "liposomal" kuphela. Ucwaningo olushicilelwe lubonise ukuzinza kwesitoreji ekwakhiweni okuthile kwe-liposomal silymarin ngaphansi kwezimo ezichaziwe. Kodwa-ke, impilo yeshelufu yezohwebo kufanele isungulwe ngomkhiqizo{4}}othize wesikhathi sangempela{5}}kanye nezifundo zokuzinza ezisheshisiwe. Le miphumela iyakhiwa{7}}iqondile futhi akufanele ihunyushwe njengezilinganiso zokusebenza kwendawo yonke yayo yonke imikhiqizo ye-liposomal silymarin.

Izinqubo zokomisa kanye nempushana{0}}zokuguqula zingathonya kakhulu ukwakheka kwe-liposomal, okuqukethwe komswakamo, ukuhlakazeka, nokuzinza okulandelayo. Ngakho-ke abathengi kufanele bacele inqubo-idatha ethile yokuzinza yempushana eqediwe kunokuba bacabange ukuthi ubuchwepheshe obuthile bokomisa buqinisekisa ubuqotho be-liposome.

 

 

Kwabathengi be-B2B abaphethei-liposomal milk thistle powderimpahla, ukugcinwa okufanele kubalulekile ukuze kugcinwe ikhwalithi yomkhiqizo kukho konke ukuphila kwawo kweshalofu.

Amapharamitha wesitoreji

Ipharamitha	Isincomo	Isizathu
Izinga lokushisa (powder)	15-25 degrees	Sebenzisa kuphela uma usekelwa idatha yokuzinza komhlinzeki
Isitoreji esiqandisiwe	2-8 degree	Ingasetshenziswa lapho iqinisekiswa ngokuqondile ekwakhiweni nasekufakweni
Isiqandisi sokugcina	Ngaphansi noma kulingana no-−20 degree	Kuphela lapho ukuqina kweqhwa kuboniswe khona
Ukukhanya Okukhanyayo	Vikela ekukhanyeni; gcina ezitsheni ezi-opaque	Ukukhanya kwe-UV kanye ne-fluorescent kungathinta ukuzinza kwezinye izakhi
Umswakama	Gcina yomile; sebenzisa amaphakheji avaliwe	Isiza ukugcina ukuqina kwempushana kanye nekhwalithi yomzimba
Umoya-mpilo	Nciphisa ukuchayeka komoyampilo; sebenzisa iziqukathi ezingangeni moya	I-oxidation iyindlela yokuwohloka
Isitsha	Iziqukathi ezingangeni moya,{0}}eziqinile ezingazweli,{1}}nomswakama	Ivimbela ukuchayeka kwemvelo

Isiqondiso Sesimo Sesitoreji Sabathengi

Isimo Sesitoreji	Lokho Abathengi Okufanele Bakulindele
15-25 degrees	Impilo yeshelufu kufanele isungulwe-yidatha ethile yokuzinza yomhlinzeki
2-8 degree	Ingase isetshenziselwe-isitoreji sesikhathi eside lapho kusekelwa idatha ethile yomkhiqizo-
Ngaphansi noma kulingana no-−20 degree	Kuphela lapho ukuqina kweqhwa kuboniswe khona
Ngemva kokuvula	Vala kabusha ngokushesha futhi unciphise ukuchayeka kumswakama, umoya-mpilo, ukushisa, nokukhanya

Isitoreji esivamile esilawulwayo singase sifanelekele ukwakheka okuthile okomile, kodwa isimo sesitoreji esiqinisekisiwe somphakeli kanye neshalofu{0}}incazelo yempilo kufanele ize kuqala. Isiqandisi kufanele sinakwe kuphela uma sisekelwa{2}}idatha ethile yokuzinza nokuqinisekiswa kwephakheji.

 

 

Ukupakishwa ngendlela efanele kuyindlela yokuqala yokuzivikela ekucekeleni phansi kwemvelo. Ngobainqwaba ye-liposomal milk thistle powder, ukupakishwa kufanele kubhekane nesithiyo somswakama, ukuvikela ukukhanya, nokukhishwa komoyampilo.

Izinketho zokupakisha

Uhlobo Lokupakisha	Kuhle kakhulu
Ukupakishwa-okuningi kwesithiyo sezendlalelo ngokudla-umugqa wangaphakathi webanga	Ukukhiqizwa kwezohwebo
Izikhwama ezivalekayo	I-R&D,-ukukhiqiza okuncane
Iziqukathi ezingangeni moya,{0}}eziqinile ezingazweli,{1}}nomswakama	Izidingo zelebula ye-OEM/yangasese

Ukucatshangelwa Okubalulekile Kwephakheji

• Impahla ye-liner yangaphakathi: I-liner yebanga-yebanga lokudla inikeza umkhawulo womswakama
• Seal ubuqotho: Iziqukathi ezingenawo umoya zivimbela ukungena kwe-oxygen kanye nomswakama
• Ukuvikela ukukhanya: Izinto zokupakisha ezikhanyayo-ezikhanyayo noma ezikhanyayo
• Veza kabusha ngemva kokusetshenziswa ngakunye: Ukuze uthole ukupakishwa okuvuselelekayo, qinisekisa ukuvala okufanele ngemva kokusetshenziswa ngakunye

 

 

 

Kubathengi be-B2B abakha imikhiqizo yezimakethe zamazwe ngamazwe, ukuqonda isimo sokulawula se-milk thistle ne-silymarin kuzo zonke izindawo ezinkulu kubalulekile.

I-United States: I-Dietary Supplement Framework

E-United States, i-milk thistle extract kanye ne-silymarin ingase ithengiswe njengezithako zesengezo sokudla, ngokuya ngezimfuneko ezisebenzayo ze-FDA zezithako zokudla, okuhlanganisa ukulebula, ukukhiqiza, nokuthobela izimangalo.

Ukucatshangelwa Okubalulekile Kwemithetho Yabathengi Be-B2B:

• Akuyona i-FDA-egunyazwe njengomuthi: I-FDA ayizange ivume ubisi lwe-milk thistle njengokwelashwa kwanoma yisiphi isimo sezokwelapha
• Ukuthobela izimangalo: Izimangalo kufanele zihambisane nezidingo ze-FDA ezisebenzayo; izimangalo zezifo zingabangela ukuthi umkhiqizo ulawulwe njengomuthi
• ukuhambisana ne-cGMP: Izithako zokudla zase-US zingaphansi kwezidingo ze-FDA, okuhlanganisa nezimfuneko ezisebenzayo ze-cGMP ngaphansi kokungu-21 CFR Ingxenye 111 yokukhiqiza izithasiselo zokudla. Abahlinzeki bezithako kufanele futhi bahlinzeke ngamadokhumenti asekela ubunikazi, ubumsulwa, amandla, ukwakheka, kanye nokucaciswa okusebenzayo kwesithako.
• Izinhlamvu eziyisixwayiso: I-FDA ikhiphe izincwadi eziyisixwayiso eziya ezinkampanini ezenza izimangalo zezifo ezingagunyaziwe zemikhiqizo ye-milk thistle. Udaba oluhlonzwe i-FDA luphathelene nokusetshenziswa okuhlosiwe kwemikhiqizo kanye nezifo{1}}ezihlobene nezimangalo ezihlobene, hhayi ukusetshenziswa kobuchwepheshe bokulethwa kwe-liposomal ngokwayo.【9†L0-L3】

I-European Union: I-Food Supplement Framework

E-EU, izithasiselo zokudla zibuswa uhlaka oluvunyelanisiwe oluhlanganisa i-Directive 2002/46/EC,【10†L0-L3】 kuyilapho uhlaka lwesengezo sokudla se-EU luvunyelaniswa ngokwengxenye, futhi izithako zesayensi yezitshalo nazo zingase zibe ngaphansi kwemithetho kazwelonke nezincazelo Ezizweni Ezingamalungu ngamanye.

Amaphuzu Abalulekile Okulawula e-EU:

• Uhlaka lwezengezo zokudla: I-Directive 2002/46/EC inikeza uhlaka oluvumelanisiwe lwezithako zokudla, kodwa isayensi yezitshalo ayivunyelaniswa ngokugcwele ezingeni le-EU, nemithetho kazwelonke esebenza kwamanye Amazwe Angamalungu.
• Isimo Sokudla Esinoveli: Isimo Sokudla Esinoveli somuthi wobisi kufanele sihlolwe ngokusekelwe engxenyeni ethile yesitshalo, isincibilikisi/inqubo yokukhipha, ukwakheka, umlando wokusetshenziswa kokudla, kanye nokusetshenziswa okuhlosiwe. Abathengi kufanele baqinisekise I-European Commission Novel Status Status Catalog kanye nencazelo efanele yezwe ngaphambi kokuthengisa.【13†L0-L3】
• Izimangalo zezempilo: Izimangalo zezempilo yokudla e-EU zingaphansi kwe-Regulation (EC) No 1924/2006 futhi kufanele zihlangabezane nezimfuneko zokugunyazwa ezisebenzayo.【11†L0-L3】 Izimangalo zezitshalo zihlala zingaphansi kwe-EU eyinkimbinkimbi kanye nezwe lokulawula likazwelonke. Abathengi kufanele baqinisekise isimo sezimangalo ezihlongozwayo Kurejista Yezimangalo Zezempilo ye-EU kanye nemithetho esebenzayo Yesifunda Selungu ngaphambi kokuthengisa.【12†L0-L3】
• Ukuhlukaniswa kwemithi: Ukuhlelwa kokulawula kuncike ekusetshenzisweni okuhlosiwe, ukwethulwa komkhiqizo, ukwakheka, nemithetho kazwelonke. Imikhiqizo ebekwe noma ethulwa njengemikhiqizo yezokwelapha ingase iwele ngaphansi komthetho wemikhiqizo wezwe noma we-EU wezokwelapha,{1}}, onezindlela ezisebenzayo zokugunyazwa kuye ngomkhiqizo, ukwakheka, izimangalo, kanye Nezwe Elingamalungu. E-France, ngokwesibonelo, i-milk thistle ibone ukusetshenziswa komuthi kanye nezithasiselo zokudla.
• Izidingo zokuhambisana: Abathekelisi kumele bahambisane nezidingo ezisebenzayo zokuphepha kokudla kanye nokulandeleka. Abathengi kufanele baqinisekise imithetho kazwelonke yezithako zesayensi yezitshalo kuSifunda Samalungu esihlosiwe.

Umehluko Obalulekile Wokulawula Wabathengi Be-B2B

Isici	USA	EU
Isimo	Isithako se-Dietary supplement	Isithako sesengezo sokudla (kuyasebenza imithetho kazwelonke)
Izilawuli zokukhiqiza	Izidingo ezisebenzayo ze-FDA cGMP zokukhiqiza izithasiselo zokudla	Ukuhlanzeka kokudla, izilawuli ezisuselwe ku-HACCP{{0}kanye nezimfuneko zokuphepha zokudla kuzwelonke/EU-
Isimo sezitshalo	Uhlaka lokulawula{0}}lwesengezo sokudla	Imithetho kazwelonke yesayensi yezitshalo ingase isebenze ngaphezu kohlaka lwe-EU-lokusekela lokudla
Izimangalo	Izimangalo zesakhiwo/zomsebenzi ngaphansi kwezidingo ezisebenzayo; izimangalo zezifo zingabangela ukuhlukaniswa kwezidakamizwa	Izimangalo zezempilo zingaphansi koMthethonqubo (EC) 1924/2006 kanye nokucatshangwa kazwelonke
Ukuhlukaniswa kwemithi	Ukusetshenziswa{0}okuhlobene nezifo okuhlosiwe kungase kubangele ukulawulwa kwezidakamizwa	Kuncike ekwethulweni, ukusetshenziswa okuhlosiwe, ukwakhiwa kanye nemithetho yeZwe eliLungu

 

 

Kochwepheshe bokuthengwa kwempahla nabaqondisi be-QA, imibhalo elandelayo kufanele itholwe kunoma iyiphiumhlinzeki we-liposomal milk thistleukusekela ukuthobela imithetho nokuqinisekisa ikhwalithi:

Idokhumenti	Inhloso
Isitifiketi Sokuhlaziya (COA)	Iqoqo-lokuhlanzeka okukhethekile, okuqukethwe kwe-silymarin, i-EE, usayizi wezinhlayiyana
Idatha yokuzinza	Izifundo ezisheshisiwe{0}}nozinzo lwesikhathi sangempela ngaphansi kwezimo zesitoreji ezichaziwe
Ishidi lokucaciswa	Ukucaciswa komkhiqizo kanye nemibandela yokwamukela
Ishidi Ledatha Yezokuphepha (SDS)	Ulwazi lokuphepha nokuphatha
Isitatimende se-Allergen	Isimemezelo sesimo esifanele sokungezwani komzimba
Okungesona-isitatimende se-GMO	Ukuze uthole-amalebula ahlanzekile
Isitifiketi se-GMP	cGMP, ISO 22000, FSSC 22000, HACCP
Isitifiketi se-Halal/Kosher	Njengoba kudingeka ezimakethe eziqondiwe

Abathengi kufanele futhi baqinisekise ukucaciswa kokupakisha, izimfuneko zesitoreji, ubuncane benani le-oda, kanye nenqwaba-ukuze{1}}ukuvumelana kwenqwaba ngaphambi kokuthengwa kwezentengiso.

 

 

Q: Iyini impilo yeshelufu evamile ye-liposomal milk thistle powder?
Impilo yeshelufu kufanele isungulwe-ngocwaningo oluthile lokuzinza lomkhiqizo kunokuba kucatshangwe kusukela esikhathini esijwayelekile. Ngaphansi kwezimo zesitoreji-eziqinisekisiwe zomhlinzeki, ukwakheka kwe-liposomal okomile kungase kusekele ukuphila kwamashalofu okuthengisa achaziwe, kodwa isikhathi esisebenzayo sincike ekwakhiweni, ekupakishweni, nasekuzinzeni kwedatha. Isitoreji esiqandisiwe ngedigri engu-4 singanweba ukuzinza ekwakhiweni okuthile; izifundo ezishicilelwe zibonise ukwakheka-ukuzinza okuncikile ngaphezu kwezinsuku ezingama-28 ngedigri engu-4 ye-silymarin ne-silibinin liposomes.

Q: Ingabe i-liposomal milk thistle powder idinga isiqandisi?
Ezakhiweni eziningi zempushana eyomile, igumbi elilawulwayo-isitoreji sezinga lokushisa lingase lifaneleke uma lisekelwa umhlinzeki{1}}idatha ethile yokuzinza. Isiqandisi (2–8℃) singase sifanele-isitoreji sesikhathi eside lapho sigunyazwe umphakeli. Isitoreji samafriji kufanele sinakwe kuphela uma sisekelwa{7}}idatha ethile yokuzinza nokuqinisekiswa kwephakheji.

Q: Ukukhanya kuthinta kanjani ukuzinza kwe-silymarin?
Ukuchayeka ekukhanyeni kungase kuthinte ukuzinza kwezinye izingxenye ze-silymarin, ikakhulukazi ngaphansi kwezimo ezinamanzi kanye nokuchayeka isikhathi eside kwe-UV. Ukuzwela kuyahlukahluka phakathi kwe-flavonolignans ngayinye. I-Liposomal milk thistle powder kufanele igcinwe ezitsheni ezikhanyayo, ezikhanyayo-ezikwazi ukumelana nezifo.

Q: Yiziphi izimpawu zokuwohloka kwe-silymarin?
Izinguquko kumbala, iphunga, ukuziphatha kabusha, noma imvula ingase ibonise ushintsho kukhwalithi yomkhiqizo, kodwa ukuhlola okubonakalayo kukodwa akukwazi ukuqinisekisa ukuwohloka kwe-silymarin. I-HPLC noma enye indlela yokuhlaziya eqinisekisiwe iyadingeka ekuhlolweni komthamo.

Umbuzo: Ingabe i-milk thistle ilawulwa ngendlela ehlukile e-USA nase-EU?
Yebo. E-USA, i-milk thistle imakethwa njengesithako sokudla futhi ayigunyazwanga i-FDA-njengomuthi. E-EU, i-milk thistle ilawulwa ngaphansi kohlaka lwezithako zokudla, nemithetho kazwelonke esebenza emazweni athile angamaLungu. Isimo Sokudla Esinoveli kufanele sihlolwe ngokusekelwe ekubunjweni okukhethekile kanye nokusetshenziswa okuhlosiwe. Izimangalo zezempilo zingaphansi koMthethonqubo (EC) 1924/2006 ngokucatshangwa kuzwelonke, futhi ukuhlukaniswa kwemithi kuncike ekwethulweni nasekusetshenzisweni okuhlosiwe.

Q: Yiziphi izitifiketi okufanele umphakeli we-liposomal milk thistle abe nazo?Ezinhlelweni eziningi zokudla -zezengezo, abathengi bangase babeke phambili izilawuli ze-GMP ezibhalwe phansi, uhlelo olwaziwayo lokuphatha ukudla -lokuphepha olufana ne-ISO 22000 noma i-FSSC 22000, kanye nezilawuli ezisekelwe ku-HACCP{4}. Izitifiketi ezengeziwe ezifana nokubhaliswa kwesikhungo sokudla se-Halal, Kosher, Organic, noma i-FDA kufanele kuhlolwe ngokuvumelana{6}}nezimfuneko zemakethe nekhasimende.

Q: Abathengi kufanele bahlole kanjani impilo yeshalofu ye-liposomal milk thistle powder?
Impilo yeshelufu akufanele ithathwe enanini lemboni ejwayelekile. Abathengi kufanele bacele umhlinzeki{1}}isikhathi esiqondile{2}}sangempela kanye nedatha esheshisiwe yokuzinza ehlanganisa izimo zokupakisha nesitoreji esinconyiwe. Idatha yokuzinza kufanele ifake amapharamitha afana nokusebenza kahle kwe-encapsulation, usayizi wezinhlayiyana, i-PDI, amandla e-zeta, nokuqukethwe okusebenzayo ngokuhamba kwesikhathi.

 

 

Ukuzinza nokuhambisana nokulawula kwei-liposomal milk thistle powderkuwukucatshangelwa okubalulekile kwabathengi be-B2B abakha imikhiqizo yezimakethe zomhlaba. I-Silymarin isengozini yokuwohloka ekukhanyeni, ekufakweni kwe-oxidation, nasekushiseni, okwenza ukugcinwa okufanele nokupakishwa kusemqoka. I-Liposomal encapsulation ingasiza ukubhekana nalezi zindlela zokuwohloka, ngezifundo ezishicilelwe ezibonisa ukuzinza ekwakhiweni okuthile ngaphansi kwezimo ezichaziwe-okuhlanganisa ukwakheka{4}}ukuzinza okuncikile ezinsukwini ezingama-28 ngedigri engu-4 ye-silymarin ne-silibinin liposomes.

Kochwepheshe bokuthenga, izinto ezibalulekile ezithathwayo zifaka: (1)gcina i-liposomal milk thistle powderku-15–25℃, ivikelwe ekukhanyeni nasemanzini{2}}esiqandisini (2–8℃) ingase ifanelekele-isitoreji sesikhathi eside lapho kusekelwa umphakeli{6}}idatha eqinisekisiwe yokuzinza; (2)qinisekisa impilo yeshalofungenqwaba-idatha ethile yokuzinza evela kumnikezeli esikhundleni sokuthatha ukuthi imiphumela eshicilelwe isebenza emhlabeni wonke; (3)baqonde izidingo zokulawulaezimakethe eziqondiwe-ubisi lwekhakhasi lunezinhlaka zokulawula ezihlukene e-USA uma kuqhathaniswa namazwe angamalungu e-EU, anemithetho ethile kazwelonke yezitshalo zezitshalo emazweni athile e-EU, imikhawulo yesimangalo sezempilo ngaphansi kwe-EU Regulation 1924/2006, kanye nokuhlukaniswa kwemithi kuye ngokwethulwa kanye nokusetshenziswa okuhlosiwe; kanye (4)cela amadokhumenti apheleleokuhlanganisa ama-COA, idatha yokuzinza, nezitifiketi zokusekela ukuqinisekiswa kwekhwalithi nokuthunyelwa kokulawula.

Emakethe lapho ikhwalithi yesithako ithinta ngokuqondile ukuphepha komkhiqizo oqediwe, ukusebenza kahle, kanye nokufinyelela emakethe, ngokubambisana neumhlinzeki we-liposomal milk thistleesihlinzeka ngedatha eqinile yokuzinza kanye nemibhalo yokulawula akuyona nje inkambiso enhle-kubalulekile empumelelweni yezohwebo.

 

Ulungele ukuhlola i-liposomal milk thistle powder ukuze uthole ukwakheka kwakho okulandelayo?Ithimba lethu lobuchwepheshe liyatholakala ukuze linikeze-idatha ethile yokuzinza kwenqwaba, ama-COA, amadokhumenti okulawula, nosekelo lokwakhiwa.

• Cela isampulaokokuhlola{0}ukuqina kwendlu kanye nokuhlolwa kokwakhiwa
• Cela iphakethe lamadokhumenti obuchwepheshe(i-COA, izifundo zokuzinza, imibhalo yokulawula)
• Buza mayelana nokucaciswa ngokwezifiso(ukugxila, usayizi wezinhlayiya, izinketho zokupakisha)
• Hlela ukubonisana kwezobuchwepheshenososayensi bethu bokwakha

[Thinta ithimba lethu le-B2B namuhla ukuze uxoxe ngezidingo zakho zokuthola usizo.]

I-imeyili:liu@wellgreenxa.com

 

 

1. Jovanović AA, Dinić S, Uskoković A, et al. I-Characterization ye-Silymarin ne-Silibinin Liposomes.Umphathi Wenqubo ye-J Eng. 2023;14(2):40-45. doi:10.7251/jepm2202040j
2. Ke Z, Cheng X, Yang H, et al. Idizayini yokubunjwa kanye nokubonakaliswa kwe-silymarin liposomes yomsebenzi othuthukisiwe we-antitumor.I-Pak J Pharm Sci. 2024;37(1):139-145. doi:10.36721/PJPS.2024.37.1.REG.139-145.1
3. I-Makouie S, Bryś J, Małajowicz J, Koczoń P. Ukubuyekezwa Okubanzi Kwe-Silymarin Extraction kanye Namasu Okufakwa Kwe-Liposomal Encapsulation Yezicelo Ezingaba Khona Ekudleni.I-Appl Sci. 2024;14(18):8477. doi:10.3390/app14188477
4. U-Bijak M. Silybin, Ingxenye Enkulu Ye-Bioactive ye-Milk Thistle (I-Silybum marianumL. Gaernt.)-I-Chemistry, Bioavailability, kanye ne-Metabolism.Amangqamuzana. 2017;22(11):1942. doi:10.3390/molecules22111942
5. Kosina P, Ryšavá A, Vostálová J, et al. Ukuzinza kanye ne-ultraviolet A photostability ye-silymarin polyphenols kanye nemiphumela yayo ekusetshenzisweni okungokoqobo kwe-dermatology.J Photochem Photobiol A Chem. 2022;429:113897. doi:10.1016/j.jphotochem.2022.113897
6. Graf TN, Polyak SJ, Ehrmann BM, Cech NB, Oberlies NH. I-UHPLC Eqinisekisiwe-I-Tandem Mass Spectrometry Method Yokuhlaziya Ubuningi be-Flavonolignans ku-Milk Thistle (I-Silybum marianum) Izingcaphuno.J Pharm Biomed Anal. 2016;126:26-33. doi:10.1016/j.jpba.2016.04.028
7. I-Bilia AR, i-Bergonzi MC, i-Gallori S, i-Mazzi G, i-Vincieri FF. Ukuzinza kwezakhi ze-Calendula, Ubisi-izithako ze-thistle kanye ne-Passionflower nge-LC-DAD kanye ne-LC-MS.J Pharm Biomed Anal. 2002;30(3):613-624. doi:10.1016/S0731-7085(02)00352-7
8. El-Samaligy MS, Afifi NN, Mahmoud EA. Ukuhlolwa kwama-hybrid liposomes-e-encapsulated silymarin mayelana nokuzinza komzimba nokusebenza kwe-vivo.Int J Pharm. 2006;319(1-2):121-129. doi:10.1016/j.ijpharm.2006.04.023
9. I-Xiao Y-Y, Ingoma Y-M, Chen Z-P, Ping Q-N. Ukulungiswa kwe-silymarin proliposome: Indlela entsha yokwandisa i-oral bioavailability ye-silymarin ezinjeni ze-beagle.Int J Pharm. 2006;319(1-2):162-168. doi:10.1016/j.ijpharm.2006.03.037
10. I-US Food and Drug Administration. I-Quicksilver Scientific, Inc. Isexwayiso, i-MARCS{4}}i-CMS 612476. Okthoba 13, 2021.
11. IPhalamende LaseYurophu kanye NoMkhandlu. Umyalelo 2002/46/EC mayelana nokulinganisa kwemithetho Yamazwe Angamalungu ephathelene nezithako zokudla. Juni 10, 2002.