Kumagundane, ukukhuluphala nokuguga kungalimaza i-biosynthesis ye-nicotinamide adenine dinucleotide (NAD +), okuholela ekungasebenzini kahle kwe-metabolic. Ukutholakala kwe-nicotinamide mononucleotide(NMN)izinga-isici esikhawulelayo ku-mammalian NAD+ biosynthesis.
Ngomhla zingama-22 kuMbasa, 2021, ithimba likaSamuel Klein waseNyuvesi yaseWashington e-United States lashicilela iphepha lokucwaninga elinesihloko esithi "I-Nicotinamide mononucleotide ikhulisa ukuzwela kwezicubu ku-insulin kwabesifazane abanesifo sikashukela" ku-Science Online. Ucwaningo lwenze i-10-isonto elingahleliwe, i-placebo-elawulwayo, Isivivinyo esiyi-double blind ukuze sihlole umthelela we-NMN supplementation emsebenzini we-metabolic wabesifazane abakhuluphele ngokweqile noma abakhuluphele ngemva kokunqamuka kokuya esikhathini.
Ngemva kokwengezwa nge-NMN, i-insulin-ukusetshenziswa kwe-glucose evuselelwe kwahlolwa kusetshenziswa i-hyperinsulinemic-hyperglycemic clamp. Ukusayina kwe-insulin yemisipha yamathambo (i-phosphorylation ye-AKT ne-mTOR) kunyukile, kodwa akuzange kushintshe ngemva kokwelashwa kwe-placebo. I-NMN supplementation up-ilawula ukubonakaliswa kwe-platelet-derived growth factor receptor kanye nezinye izakhi zofuzo ezihlobene nokulungiswa kabusha kwemisipha. Le miphumela ikhombisa ukuthi i-NMN ingakhuphula ukuzwela kwezicubu ku-insulin, ukusayina kwe-insulin kanye nokulungiswa kabusha kwabesifazane abakhuluphele ngokweqile noma abakhuluphele ngaphambi{7}}abanesifo sikashukela.
Uma ufuna isaphulelo esikhulu noma isampula yamahhala , sicela ukhululeke ukuxhumana :liu@wellgreenxa.com,Siyabonga.Sinesitoko esanele esingasithumela.
