I-Puerarin, eyaziwa nangokuthi i-Pueraria lobata flavonoids, iyi-isoflavone yemvelo ye-carbon glycoside eyingxenye ebalulekile yokusebenza ngempumelelo kokwelapha kwe-Pueraria lobata. I-Puerarin isetshenziswa ngokomtholampilo ekwelapheni isifo senhliziyo nemithambo yegazi, umdlavuza, isifo sika-Parkinson, isifo se-Alzheimer, isifo sikashukela nesifo sikashukela ngenxa ye-hypoglycemic, i-lipid-regulating, i-vascular-protective, antioxidant, anti{3}}anti infective kanye ne-insulin{4}}sensitive index imiphumela enemiphumela embalwa emibi.
01
Ukwelashwa kwesifo sikashukela
I-Puerarin ingakwazi ukwelapha isifo sikashukela ngokwehlisa izinga likashukela egazini, futhi ivimbele umsebenzi we-alpha-glucosidase, ngaleyo ndlela yehlise ukugcwala kweglucose egazini ngenjongo yokwelapha isifo sikashukela. Kwatholakala ukuthi ukwelashwa kweziguli ezinesifo sikashukela sohlobo 2 nge-Puerarin kungathuthukisa ukuzwela komzimba ku-insulin, kanti i-Puerarin inganciphisa ukumelana ne-insulin, ngaleyo ndlela yelaphe isifo sikashukela. I-Puerarin ingaphinda ivimbele ukukhiqizwa kwe-TNF- ku-plasma, ithuthukise izinga lokuzwela komzimba ku-insulin, kanye nezinga likashukela egazini lehle. Ngaphezu kwalokho, i-Puerarin ku-retinopathy yesifo sikashukela isiza ukunciphisa ukumelana nokugeleza kwegazi emithanjeni ye-fundac, isheshisa ukugeleza kwegazi, ithuthukise ukunwetshwa kwemithambo yemisipha, inciphise ukwakheka kwe-thrombosis yendawo, futhi inomphumela wokuvimbela ku-retinopathy yesifo sikashukela, kanti i-Puerarin nayo inomphumela wokwelapha isifo sikashukela sokukhulelwa.
02
I-Anti{0}}umphumela wesimila
I-Puerarin inomphumela obalulekile wokuvinjelwa ekwandeni kwamangqamuzana e-tumor, futhi inomthelela wokwelapha kumaseli wesimila ngokukhuthaza i-apoptosis yamaseli wesimila. Imiphumela yabonisa ukuthi uma kuqhathaniswa neqembu lokulawula, amazinga okuveza iphrotheni Akt ehle kakhulu eqenjini eliphathwe nge-Puerarin, kuyilapho amazinga okuvezwa kwe-apoptosis proteins Bax, Fas, caspase-3 kanye ne-caspase-8 anda, okubonisa ukuthi i-Puerarin inganqanda ukwanda komsebenzi womdlavuza wendlala yesinye ngokulawula kabusha umsebenzi wamaseli womdlavuza we-prostate. Futhi amazinga enkulumo yakho kokubili i-caspase-3 kanye ne-caspase-8 anyuswa, okubonisa ukuthi i-Puerarin inganqanda ukwanda kwamangqamuzana omdlavuza wendlala yesinye ngokulawula umsebenzi wokusabalala kweprotheyini i-Akt, futhi ikhuphule ukuvezwa kwamaphrotheni e-apoptotic i-Bax ne-Fas, engenza kusebenze i-apoptotic signaling pathway ye-capasepase eholela ekugcineni kwe-3. Ngaphezu kwalokho, i-puerarin ingaphinda ibangele i-apoptosis kumaseli wesimila ngokusebenzisa indlela encike ku-mitochondria. Kumaseli e-hepatocellular carcinoma, i-cytochrome c ekhishwe ku-mitochondria isebenzisana ne-adenosine triphosphate kanye ne-apoptosis protease ukuze kusebenze i-caspase-9 ne-caspase-3, okuholela ku-apoptosis encike kuseli ye-hepatocellular carcinoma. I-Puerarin ikhuthaza i-apoptosis yamaseli e-tumor ngokwenza kusebenze indlela ye-TLR4 / NF-κB, ngaleyo ndlela ivimbele ukukhula kwesimila. Emigqeni yamangqamuzana omdlavuza we-colon, i-Puerarin ikhuthaze ukusebenza kwe-TLR4 expression factor, indlela ye-PI3K/Akt evuliwe, okuholele ekuvezweni kweprotheyini eqondiwe ephansi yomfula i-NF-κB yokubhala isici, izinga eliphakeme le-caspase-3 le-protein expression, kanye ne-apoptosis eyenza i-apoptosis yamaseli e-colon tumor.
03
Umphumela wokuvikela esibindini
I-Puerarin inomphumela wokuvikela ekulimaleni kwesibindi okubangelwa ukuphuza utshwala. I-Glutathione ALT, i-glutathione AST kanye nenani le-cholesterol ye-CHOL kwandiswe ngendlela engavamile ekulimaleni kwesibindi okubangelwa izici ezihlukahlukene. Kutholwe ukuthi amaleveli okuvezwa kwe-ALT, AST kanye ne-CHOL ayephezulu kakhulu eqenjini lemodeli uma kuqhathaniswa neqembu lokulawula, kuyilapho amaleveli ephrotheni ngayinye ayephansi eqenjini elilashwe i-geranium-kunaseqenjini eliyimodeli. Ngaphezu kwalokho, kutholwe ukuthi ukubonakaliswa kwe-ALT, AST, ALP kanye-nama-cytokines avuthayo IL-1 , IL-6 ne-TNF- ayephansi kakhulu eqenjini elilashwe i-geranium-uma kuqhathaniswa neqembu elilawulayo kumodeli ye-alcohol ebangelwa utshwala engabangela ukulimala kwesibindi okungapheli, okuphakamisa ukulimala okungapheli kwesibindi. inqubo yokuvuvukala.
04
I-Anti-i-arrhythmic ne-anti{1}}imiphumela ye-angina
Ucwaningo luye lwabonisa ukuthi umjovo wePuerarin unemiphumela ethile ekwelapheni i-angina pectoris ku-coronary heart disease. Umshini uhlanganisa: okokuqala, ukwehlisa izinga lokushaya kwenhliziyo kanye nezinga lomfutho wegazi, ukuthuthukisa izimpawu ezibalulekile, ukunciphisa ukusetshenziswa kwe-oksijini ye-myocardial, ukuvuleka kwemithambo ye-coronary, ukuthuthukisa i-myocardial hypoxia, ischemia kanye nezinkomba ze-rheology yegazi; okwesibili, ukwehlisa i-viscosity yegazi, okunomthelela wokuthambisa imithambo yegazi, ukuthuthukisa i-atherosclerosis, ukulungisa amangqamuzana e-vascular endothelial nokumisa ukuwohloka kwezifo. Ucwaningo luqinisekisile ukuthi ukusetshenziswa komjovo we-deer antler gum ekwelapheni iziguli esezikhulile ezine-angina pectoris ye-coronary heart disease kungathuthukisa ukugula kuyilapho kubangela i-vasodilatation, kunciphise i-hypoxia-i-ischemia nokuthuthukisa ngokwengeziwe izinkomba ezihlukahlukene ezifana ne-rheology yegazi kanye ne-myocardial oxygen consumption index enomphumela omuhle.
