Imiphumela ohlelweni lwenhliziyo nemithambo yegazi
I-Puerarin ingadlala indima ephumelelayo ye-antihypertensive ezilwaneni ezinomfutho wegazi ophakeme. I-Puerarin ingakhuthaza ukugeleza kwegazi le-microvascular yendawo kanye nokunyakaza kokwanda kwe-amplitude, okuholela ekusheshiseni ukujikeleza kwegazi, kukhuthaze ubuchopho be-microcirculation evamile yomzimba womuntu, kunciphise izithiyo ze-microcirculation. Ngaphezu kwalokho, i-puerarin ingadlala indima enhle ekuthuthukiseni i-microcirculation ye-nail wrinkle yeziguli ezinokungezwa okungazelelwe. I-Puerarin ingasusa ukuminyana kwemithambo yegazi, isheshise ukugeleza kwegazi, ukuze ekugcineni ibuyisele ukuzwa kweziguli. I-Puerarin ingasiza ekwelapheni i-arrhythmia. I-Puerarin iqukethe izivimbeli ze-beta{5}, ezilwa nokushaya kwenhliziyo ngaphambi kwesikhathi kanye ne-ventricular tachycardia, enciphisa izehlakalo ze-arrhythmias. I-Puerarin inganciphisa i-tachycardia futhi idlale indima enhle ekwelapheni i-arrhythmia emtholampilo. I-Puerarin ingavikela i-ischemic myocardium, ikhuphule ukugeleza kwegazi kwe-ischemic myocardium futhi ikhuphule ukugeleza kwegazi okuhlangene ukuze kwelaphe i-ischemic myocardium.
Isicelo:
I-Puerarin yesicelo somtholampilo ibanzi, hhayi kuphela i-angina, isifo senhliziyo, i-myocardial infarction kanye nezifo zesimiso senhliziyo ezifana nomfutho wegazi ophakeme zinenani lomtholampilo, ngenxa yezifo zesimiso senhliziyo, ngokusebenzisa i-puerarin ingasebenza imithambo yegazi, ithuthukise isimo senhliziyo, inciphise ingozi yesifo senhliziyo. Ngaphezu kwalokho, ukusetshenziswa kwe-puerarin kungadlala nomphumela othile wokwelashwa komtholampilo ekuvinjweni kwe-retinal arteriovenous, i-optic nerve atrophy, ukungezwa okungazelelwe kanye nezinye izifo.
I-Puerarin iye yaqashelwa abantu abaningi ngomsebenzi wayo obanzi wezokwelapha, ukusebenza kahle okucacile kanye nemiphumela emincane enobuthi nemiphumela engemihle. Nokho, ukuncibilika kwe-lipid okungekuhle kwe-puerarin nokuncibilika kwamanzi kanye ne-bioavailability ephansi nakho kukhawulela ukusetshenziswa kwayo. Kodwa-ke, eminyakeni yamuva nje, ngenxa yokusetshenziswa kwezinto eziphezulu ze-polymer ye-biocompatibility, izinhlobonhlobo zamalungiselelo e-puerarin nano ziye zathuthukiswa, njenge-liposomes, i-nanocrystalline / granule, ama-polymer micelles, ama-microemulsions, ama-dendrimers, njll, okwenza i-puerarin ihlakazeke ngokulinganayo futhi kube lula ukungena nge-biofilm. Uma kuqhathaniswa namathebulethi avamile asheshayo asheshayo - akhishwayo, amaphilisi ohlaka lwamathambo, ama-solid dispersions kanye namanye amalungiselelo okukhishwa ahamba kancane -, ukunyibilika, ukuzinza kanye nokuba khona kwe-bioavailability kuyenyuka. Ngokuthuthuka okuqhubekayo kwethiyori ye-pharmacology kanye nenqubekelaphambili eqhubekayo yobuchwepheshe besimanje bezokwelapha, ucwaningo lwe-puerarin nalo lujule-kakhudlwana, i-puerarin izoba nethemba elibanzi esikhathini esizayo.
