Izinhlanganisela ze-Curcumin, okuyi-curcumin ephelele, ziyizingxenye ezisebenzayo ezikhishwe ezimpandeni neziqu ze-ginger nezitshalo ze-araceae, ikakhulukazi ezihlanganisa i-curcumin, i-demethoxylcurcumin ne-dimethoxylcurcumin. Njengamanje, i-curcumin ngokuvamile ibhekwa njengengxube yalezi zingxenye ezintathu, lapho i-curcumin ibala i-70% ye-curcumin ephelele, futhi iphinde ibe yingxenye eyinhloko ye-curcumin compounds ukudlala umsebenzi wayo.
I-Curcumin inamaqembu amaningi e-phenolic hydroxyl futhi iyimpushana ephuzi ephuzi e-crystalline engancibiliki emanzini. I-curcumin ekudleni isetshenziswa kakhulu emikhiqizweni yesoseji, ekheniwe, isoso LuZhiPin umbala, njengakwezokwelapha, i-curcumin ku-anti-isimila, -eqeda ukuvuvukala, i-antioxidant, i-scavenging free radicals, i-antimicrobial kanye nesistimu yenhliziyo, isistimu yokugaya ukudla nezinye izici zinezinhlobonhlobo zezakhiwo zayo zokuvikeleka zekhemisi zihle, kodwa i-curcumin ayiyona imiphumela emihle ye-pharmacological. ezinzile, i-metabolism esheshayo emzimbeni, Ngenxa yalokho, i-bioavailability yayo iphansi kakhulu futhi ayisetshenziswa kabanzi emisebenzini yomtholampilo. Kuleli phepha, i-bioavailability ye-curcumin, izindlela zokuthuthukisa i-bioavailability ye-curcumin kanye nenqubo ye-biotransformation, ukumuncwa kanye ne-metabolism ye-curcumin emzimbeni womuntu kubuyekezwa.
01 Isakhiwo se-curcumin
I-molecular formula ye-curcumin yi-C21H206, isisindo se-molecule singu-368.37g/mol, futhi indawo yokuncibilika yi-183 degree. I-Curcumin icwebezelwe. I-pigment eyivelakancane ene-diketone emhlabeni wezitshalo, eyakhiwe ngama-o{6}}methylated phenols amabili kanye -ne-diketone. -Isakhiwo se-diketone sine-anol{10}}isakhiwo esisodwa se-tautomatic, kodwa ukwakheka kwe-spectral kufakazela ukuthi i-curcumin ikakhulukazi ikhona ku-enol eqinile nesisombululo.
Ukunyibilika nokuzinza kwe-curcumin kuncike ohlotsheni lwe-solvent ne-pH. I-Curcumin ayincibiliki kakhulu emanzini, kodwa incibilika kuma-organic solvents. I-Curcumin izinzile ngaphansi kwezimo ze-acidic ezingathathi hlangothi. Ngaphansi kwezimo ze-alkaline, i-curcumin ayizinzile futhi ihlephuka kalula ibe nombala ophuzi noma onsundu.
02 Umsebenzi we-Physiological we-curcumin
I-Curcumin iqukethe inani lezibopho eziphindwe kabili, kanye namaqembu e-phenolic hydroxyl kanye ne-carbonyl, ngakho inomsebenzi oqinile we-physiological. Ucwaningo lubonise ukuthi i-curcumin ine-anti-isimila,{2}}iqeda ukuvuvukala, i-antioxidant, i-free radical scavenging, i-anti{3}}isistimu yama-microbial ne-cardiovascular, isistimu yokugaya ukudla neminye imiphumela eminingi.
2.1 i-antitumor
Ucwaningo lwezokwelapha luye lwabonisa ukuthi i-curcumin, njengenhlanganisela yemvelo, inamandla amakhulu okulwa nomdlavuza, futhi i-National Cancer Institute (NCI) ibhale njengesizukulwane sesithathu se-chemoprevention agents. Inombolo enkulu yocwaningo ibonise ukuthi i-curcumin ingavimbela ukwanda kwezinhlobonhlobo zamangqamuzana omdlavuza, futhi akukho miphumela ecacile enobuthi nemiphumela emibi etholakele lapho umthamo womlomo wawungu-5g / kg kumagundane. I-In vitro, in vivo, kanye nezivivinyo zomtholampilo zabantu zikuqinisekisile ukusebenza kanye namandla e-curcumin ezinhlotsheni eziningi zomdlavuza. Indlela yayo yokulwa nomdlavuza ikakhulukazi ngokufaka i-apoptosis yamaseli wesimila, futhi indlela yawo yamangqamuzana elwa nomdlavuza isifundwe kabanzi.
2.2 ukulwa-nokuvuvukala
Ukunqanda{{0}ukuvuvukala okunamandla futhi okungapheli kuyisici esiyinhloko ekwakhekeni kokukhuluphala ngokweqile, uhlobo lwe-II lwesifo sikashukela, isifo samathambo, i-pancreatitis, isifo senhliziyo nemithambo yegazi, izifo ze-neurodegenerative kanye ne-metabolic syndrome, nezinhlobo eziningi zomdlavuza. I-Curcumin isetshenziswe{{2}njengomuthi ovimbela ukuvuvukala amakhulu eminyaka. Inombolo enkulu yocwaningo iqinisekise umphumela wayo wokulwa{{4}nokuvuvukala nendlela yayo, futhi inamazinga ahlukene okuvimbela ukuvuvukala okubangelwa izimbangela ezihlukahlukene, futhi inemiphumela engemihle emincane kakhulu kanye nokusabela okubi, okunezinzuzo ezisobala uma kuqhathaniswa nezinye{5}}izidakamizwa ezilwa nokuvuvukala.
2.3 i-antioxidant
I-Curcumin, njengenhlanganisela yemvelo, ingasusa ngokuqondile ama-radicals mahhala ku-vivo kanye ne-in vitro, futhi umsebenzi wayo wokulwa ne-antioxidant ungaqhathaniswa -ne-carotene, i-anthocyanin nezinye izingulube zemvelo, futhi olunye ucwaningo luye lwabonisa ukuthi i-curcumin inekhono elingcono lokulwa ne-antioxidant kunamavithamini avamile. Ikhono le-Curcumin lokuvimbela kanye nokwelapha izifo eziningi nalo kucatshangwa ukuthi lihlobene nemiphumela yalo ye-antioxidant.
2.4 I-Neuroprotection
Izifo ze-Neurodeergenerative ziwuhlobo lwezifo ezibangelwa ukungasebenzi kahle kwesistimu yezinzwa, okuhlanganisa nesifo i-Alzheimer's, isifo sikaParkinson nezinye izifo, akukho ukwelashwa okuphumelelayo okwamanje. Ucwaningo lwakamuva lubonise ukuthi i-curcumin inomphumela we-neuroprotective. I-Curcumin ivikela amaseli e-PC12 kubuthi be-beta-i-amyloid ngokuvimbela ukulimala kwe-oxidative kanye ne-tau hyperphosphorylation. UMa et al. i-curcumin ejovwe, i-mecobalamin kanye ne-saline evamile emgodini we-intraperitoneal wamagundane anokulimala kwezinzwa ngokulandelana kwamaviki e-4 ukuze kuqhathaniswe. Ukuvuselelwa kwe-axonal kwahlaziywa ngokulebula kabusha kwe-retrograde kanye ne-morphometry, futhi ukuvuselelwa komsebenzi wemoto kwahlolwa nge-electrophysiology, ukuziphatha, ukubukeka kwe-histological nezinye izinkomba. Ukuhlaziywa kwedatha kubonise ukuthi amaqembu wokwelapha we-curcumin kanye ne-mecobalamin azuze ukuvuselelwa kwezinzwa ezinhle kanye nokululama kokusebenza.
2.5 I-Anti{1}}i-fibrosis
I-Fibrosis ingaholela ekubhujisweni kwesakhiwo sezitho, ukungasebenzi, ukwehluleka, kuthinte kakhulu izinga lempilo yeziguli. Ucwaningo luye lwabonisa ukuthi i-curcumin inomsebenzi osobala wokulwa-nomzimba we-fibrosis futhi inemiphumela yokwelapha ku-liver fibrosis, i-pulmonary fibrosis kanye ne-renal fibrosis, njll. Nokho, indlela yayo yokulwa{3}}ne-fibrosis idinga ukucutshungulwa, kanye nendlela yokuthuthukisa i-bioavailability ye-curcumin ukuze kuthuthukiswe inkinga yokwelapha yangaphandle futhi kuxazululwe inkinga yangaphandle yokwelapha futhi ixazululwe.
2.6 Thuthukisa ukuphazamiseka kwe-microflora yamathumbu
Amagciwane ahlala emathunjini omuntu abizwa ngokuthi "i-intestinal flora", edlala indima ebalulekile ekugayeni ukudla, ukuzivikela komzimba kanye nokumelana nezifo. Basesilinganisweni esiguqukayo ngaphansi kwezimo ezijwayelekile. Kodwa-ke, uma i-flora yamathumbu ingalungiswa kahle, izoba nemiphumela emibi emzimbeni, njengokukhuluphala, isifo sikashukela, umfutho wegazi ophezulu nezinye izifo ezihlobene nokuphazamiseka kwezitshalo zamathumbu. Ucwaningo luye lwabonisa ukuthi i-curcumin ingakwazi ukulawula izitshalo zamathumbu ezifana ne-Escherichia coli ne-Bacteroidetes ukuze zibuyisele ibhalansi yazo enamandla. U-Li Yun et al ufakazele ukuthi i-curcumin ingathuthukisa ukudangala kanye nokuphazamiseka kwe-microflora yamathumbu okubangelwa ukulala ngezikhathi ezithile kumagundane. Ngaphezu kwalokho, impande ye-turmeric nayo inemisebenzi yomzimba efana nokwehlisa ushukela osegazini, ukuthuthukisa isifuba somoya esingezwani nomzimba, i-anti-amagciwane kanye{6}}ne-HIV.
03 Ukusetshenziswa kwe-curcumin
I-Curcumin, njenge-acid ephuzi yemvelo ye-phenolic pigment, isetshenziswa kabanzi futhi inamandla amakhulu okuthuthuka. I-Curcumin, njengommeleli wezingulube zemvelo, iphephile kunezingulube zokwenziwa. Njengamanje, i-curcumin ingenye yemibala eyisikhombisa yokudla yemvelo ethengiswa kakhulu emhlabeni. Kuqashelwa njengesengezo sokudla semvelo yi-WHO kanye ne-FDA, futhi isetshenziswa kakhulu ekufakeni imibala kokudla kukaswidi, ukugoqa okuyimpushana kanye nelayisi nama-noodle osheshayo. Futhi ngenxa{4}}yokulwa nomdlavuza, i-antioxidant kanye neminye imisebenzi ye-physiological, ingasetshenziswa njengemithi yokwelapha izifo. Njengamanje, i-curcumin capsule ingene emakethe yemikhiqizo yokunakekelwa kwezempilo, izifundo zomtholampilo zibonise ukuthi i-curcumin capsule ye-cardiovascular system isifo, isifo sesisu, nomdlavuza kunomphumela othile wokwelapha, kungase futhi kube i-curcumin esetshenziselwa izimonyo kanye nemikhiqizo yezempilo, kodwa ngenxa ye-curcumin engancibiliki kahle emanzini, i-bioavailability ephansi kakhulu, inciphisa isenzo se-pharmacy curcumin.
