I-Yam powder-kuthathwe kokuthiI-Dioscoreaizinhlobo ezifanaD. villosa(i-yam yasendle) kanyeD. ngokuphambene(I-yam yesi-Chinese)-iletha ama-saponins e-steroidal ahlukile (diosgenin), isitashi esingazweli, ne-allantoin. I-WellGreen isebenzisa i-supercritical CO₂ extraction ukukhiqiza izimpushana ezijwayelekile (Ezinkulu noma ezilingana ne-40% diosgenin) eziguqula amakhambi endabuko abe yizixazululo zesimanje zokwelapha.
Izinzuzo Zezempilo Eziqinisekisiwe Ngomtholampilo
a) Impilo Yamahomoni Yabesifazane
- IndlelaI-Diosgenin iguqula i-estrogen/progesterone receptors (khetha i-ER agonist) ngaphandle kokwanda kwamahomoni e-serum
- Ubufakazi Bomtholampilo: 500mg impushana yasendle nsuku zonke yehlisa ukushisa okushisayo ngo-52% uma kuqhathaniswa ne-placebo (Ukunqamuka kokuya esikhathini, 2023)
- Umkhawulo Wokuphepha: Ayikho ingozi yokuqina kwe-endometrial (iyahluka ku-HRT)
b) Ukulawulwa Kwe-Metabolic & Blood Sugar
| Isenzo | Inhlanganisela esebenzayo | Ukusebenza kahle |
|---|---|---|
| Ukuzwela kwe-insulin | I-Dioscin | Ukwenza kusebenze i-AMPK → 27% ngaphansi kwe-HOMA-IR |
| I-Carb Blockade | Isitashi esingazweli | Yehlisa ukumuncwa kweglucose ngo-41% |
Umthamo: 3g Chinese yam powder ngaphambi{1}}kwesidlo sehlise i-postprandial glucose ngo-34% (J. Ethnopharmacol{1}})
c) Ukusekelwa Kwezithiyo Zamathumbu
- I-Allantoin: Ivuselela ukukhiqizwa kwe-mucin (ukulawulwa kofuzo lwe-MUC2)
- I-Prebiotic Fiber: OkuphakelayoI-Bifidobacteria→ 22% ukukhiqizwa kwe-SCFA okuphezulu
Izicelo Zokusika-Izimboniumbhalo
a) Amafomula we-Nutraceutical
| Ithagethi | Ifomula ye-Synergistic | I-WellGreen Innovation |
|---|---|---|
| Ukwesekwa kokuyeka ukuya esikhathini | I-Yam + Black Cohosh (2:1 isilinganiso) | Ibambezelekile-ukukhishwa kwama-capsules ukuze isebenze kahle amahora angu-24 |
| Impilo Ye-Metabolic | I-Yam + Berberine (3g:500mg) | I-Enteric coating ivimbela ukuwohloka kwesisu |
| I-Vegan Probiotics | Yam powder +I-Bacillus coagulans | I-Prebiotic-probiotic co-encapsulation |
b) Ukudla Okusebenzayo
- Ukuphathwa Koshukela Wegazi: 10% yam powder ku-pasta (ithatha indawo kafulawa kakolweni) → Inkomba ye-glycemic yehliswe ngo-35%
- I-Gluten-Ukubhaka Kwamahhala: Ibopha amanzi ka-5x kangcono kune-tapioca (ithuthukisa ukuthungwa)
c) Izimonyo
- I-Diosgenin Creams: Ivuselela ukuhlanganiswa kwe-collagen I (ukunyuka okungu-109% uma kuqhathaniswa ne-retinol*)
- I-Allantoin Serum: Ilungisa izithiyo zesikhumba ezisengozini (TEWL ↓63% emavikini angu-4)
Izithenjwa
- Malaivijitnond et al. (2023).I-Diosgenin Modulates ER Ngaphandle Kwemiphumela Ye-Uterotrophic. J. Steroid Biochem. UMol. I-Biol.
- WellGreen. (2024).Ukuhlolwa Komtholampilo: I-Wild Yam Powder Kwabesifazane AbaseMenopausal(Idokhumenti #WGXA-YAM-2024).
- Iphaneli ye-EFSA. (2024).Ukuphepha kwe-Dioscorea villosa Extracts(EFSA-Q-2024-15793).
