I-Oleanolic acid iwuhlobo lwe-pentacyclic triterpenoids etholwe ngokuhlukanisa nokukhipha esithelweni saso sonke isitshalo sesitshalo se-Gentianaceae, uhlobo lohlobo lwe-Syringa japonica noma i-Ligustrum lucidum. Ucwaningo lwesimanje lwe-pharmacological luqinisekisile ukuthi i-oleanolic acid inganciphisa kakhulu ukuphakama kwe-serum alanine aminotransferase, inciphise ukuwohloka kwamangqamuzana esibindi kanye ne-necrosis, ukusabela kokuvuvukala kwezicubu zesibindi kanye nenqubo ye-fibrosis, ikhuthaze ukuvuselelwa kwamangqamuzana esibindi, isheshise ukulungiswa kwezicubu zesibindi ze-necrotic, ivimbele I-Non{1}}impendulo ye-protein eqondile, futhi inomphumela oqondile wokuvuvukala. Ukubuka kwe-Ultrastructural kubonisa ukuthi i-oleanolic acid ingavikela futhi izinze ulwelwesi lwe-lysosomal kanye ne-biofilm ye-organelles, ibuyisele ukukwazi kwayo ukungena kanye nemisebenzi yokuthutha esebenzayo, ibuyisele ukunyakaza kwama-ion namanzi e-intracellular nama-extracellular, futhi ixegise i-cytoplasm nebhaluni{3}}njengama-hepatocyte abuyela esimweni esivamile, amandla okuvuselela, ukuvimbela ukuvuvukala kanye ne-fiber eqinisiwe. Ukuhlolwa kwe-in vitro kubonise ukuthi i-oleanolic acid ingavimbela ukwanda kwamaseli we-leukemia ngokunciphisa ukubonakaliswa kwe-vascular endothelial growth factor. Ilungele ukwelapha i-viral hepatitis, futhi ingathuthukisa izimpawu, izimpawu nokusebenza kwesibindi, ilungise ukuphazamiseka kwe-protein metabolism futhi ibe nemiphumela ethile yokuqeda{6}}isimila.
Mayelana nokuphepha, inani elincane lamacala abhekana nomlomo owomile, isifo sohudo, nokungakhululeki kwesisu esingenhla ngemva kokuthatha i-oleanolic acid, eyanyamalala ngemva kokwelashwa okunezimpawu. I-thrombocytopenia emnene yenzeka ezimweni ezingazodwana, ezingatholakala ngemuva kokuyeka umuthi.
I-Matrine iwuhlobo lwe-alkaloid ekhishwe futhi yahlukaniswa ne-Sophora japonica, isitshalo sohlobo lwe-Sophora, ikakhulukazi i-oxymatrine, futhi iqukethe inani elincane le-oxymatrine. I-Matrine inomphumela wokwandisa ama-leukocyte, futhi inomphumela ocacile wokwelapha ku-leukopenia; inomphumela wokuvikela ekulimaleni kwesibindi, i-serum alanine aminotransferase iyancipha, i-necrosis yesibindi nokuvuvukala kuyancipha, futhi ukulungiswa kwezicubu zesibindi kuyanda; ukuhlolwa kwe-in vitro kanye ne-vivo kubonisa ukuthi, Inomphumela othile wokuvimbela ukuphindaphinda kwegciwane le-hepatitis B; inganciphisa ukungeneka kwama-capillaries, ivimbele ukwanda kwezicubu ze-granulation, ilawule ukukhululwa kwe-histamine, i-leukotrienes nabanye abaxhumanisi kumaseli e-mast yesibindi, futhi ivimbele ukukhululwa kwama-leukocyte ku-lipopolysaccharide{1}}induced mouse peritoneal macrophages. Ama-cytokines afana ne-IL-1, i-interleukin{7}}6, i-tumor necrosis factor{8}}, njll., anawo{9}}i-steroidal hormone{10}}njengemiphumela{11}}eqeda ukuvuvukala kanye ne-anti-allergic; ingavimbela ukwanda kwamaseli e-hepatic stellate futhi ibe nemiphumela elwa ne-hepatic fibrosis; Umphumela we-Immunomodulatory, futhi ungavimbela ngempumelelo noma ubambezele ukwenzeka komdlavuza wesibindi. Ilungele ukwelashwa kwe-hepatitis B engapheli, i-hepatitis B fibrosis, i-leukopenia ebangelwa i-radiotherapy yesimila, i-chemotherapy kanye ne-leukopenia ebangelwa ezinye izizathu. I-Adjuvant therapy ye-eczema eyingozi futhi engapheli kanye ne-herpes zoster.
Mayelana nokuphepha, ukusabela okubi okuvamile kwe-matrine ukwanda kwesikhashana kwe-alanine aminotransferase, okungathuthukiswa ngemithi eqhubekayo. Kungase kube nesicanucanu, ukuhlanza, ukunambitheka okubabayo, isifo sohudo, ukungakhululeki noma ubuhlungu be-epigastric, njll. Ngezinye izikhathi, kungase kube nokuqubuka kwesikhumba, ukucinana kwesifuba, kanye nemfiva, futhi izimpawu ezingenhla ngokuvamile ziyazikhulula.
I-Silibinin iyi-antioxidant, ekhishwe esitshalweni esibizwa ngokuthi i-milk thistle, engakwazi ukuzinzisa ulwelwesi lwamangqamuzana esibindi, ivikele uhlelo lwe-enzyme yamangqamuzana esibindi, isuse ama-radicals oksijini asebenzayo kumaseli esibindi, ngaleyo ndlela ithuthukise ikhono lokuqeda ubuthi besibindi, Ithuthukise ukusebenza kwesibindi futhi ikhuthaze ukuvuselelwa kwamaseli esibindi. Imiphumela yokuhlolwa kwemithi kanye ne-toxicological ibonisa ukuthi i-silibinin inamazinga ahlukene emiphumela yokuvikela neyokwelapha ezinhlotsheni ezihlukahlukene zokulimala kwesibindi okubangelwa ubuthi besibindi, izidakamizwa zokulwa-nofuba, i-sepsis, njll., futhi ingavimbela ukuphakama kwe-aminotransferase ngezinga elithile. umphumela. Imiphumela yokuhlola ibonisa ukuthi i-silibinin inganqanda ukwanda kwamangqamuzana esibindi kanye nokuhlanganiswa kwe-collagen, inomphumela othile wokulwa{5}}ne-fibrotic, inganqanda izinkinga zesifo sikashukela ngokuthuthukisa ukuphuma kwe-lipid peroxide, futhi ingandisa ukuzwela kwe-insulin ku-vivo. Ilungele ukwelashwa kokusebenza okungavamile kwesibindi ekulimaleni kwesibindi esinobuthi nesokuzivikela komzimba, i-hepatitis eyingozi futhi engapheli, nesibindi esinamafutha anotshwala. Futhi ube nokuphikisana okuthile kwe-fibrosis yesibindi. Inemiphumela ethile yokuvimbela kanye nokwelapha ezinkingeni zesifo sikashukela kanye nezifo ezihlobene ne-insulin-. Uma isetshenziselwa ukwelapha isibindi esinamafutha kanye ne-cirrhosis, kutuswa ukuthi ungadli{11}}ukudla okunamafutha aphezulu kakhulu. Ukwelashwa kwesondlo kungasetshenziswa ekwelapheni ukulimala kwesibindi okubangelwa{13}}ukudakwa isikhathi eside nokubhema.
