Ukuthuthukiswa okusimeme kwemithombo yemithi yaseShayina eyigugu nesengozini kuwudaba olubalulekile lwesayensi oludinga ukubhekwana nayo imboni yezokwelapha yaseShayina. Ukhuni lwe-Aquilaria sinensis (Lourl.) Gilg luwukhuni olunezinhlaka olwakheka kancane kancane ngemva kokuba isitshalo i-Aquilaria sinensis (Lourl.) sihlaselwe, futhi iyisitshalo esibalulekile nesinongo ngenxa yekhono laso lokuhambisa i-qi nokukhulula ubuhlungu, ukuhlanza okufudumele kanye nesifuba somoya esizolile. Ngenxa yephunga layo eliyingqayizivele, ibalwa njengenye yempepho ezine ezidumile "ze-sandalwood eshisiwe ne-dragon musk", futhi intengo ngegremu ngayinye yempepho yekhwalithi ephezulu ingafinyelela izinkulungwane zamaRandi, ijabulela idumela elithi "diamond in the wood". Impepho emhlophe iwukuphela komthombo wamakhambi empepho eShayina, futhi iyisitshalo sokwelapha esingavamile nesibalulekile esiyingqayizivele eShayina. Ngenxa yezinga layo eliphansi lokuzala kwemvelo nokugawulwa kwezilwane eziyingozi, izinsiza zehlathi nendawo ezungezile zilimele kakhulu futhi imithombo yasendle isengozini yokuncipha, futhi ifakwe ohlwini lweSithasiselo II seNgqungquthela Yokuhweba Ngamazwe Ngamazwe Ngezinhlobo Ezisengozini Yezilwane Nezitshalo Zasendle (CITES) futhi iyisitshalo esivikelekile seBanga II eChina. Ngaphansi kwezimo zemvelo, impepho ikhiqizwa ikakhulukazi izinambuzane, izifo zesikhunta, ukulimala kwangaphandle nezinye izici ezibangela ukusabela kokuzivikela, futhi ukukhiqizwa kwayo kwempepho kuhamba kancane futhi kuphansi kakhulu. Ukucacisa indlela yokwakheka kwempepho kanye nokungenelela ohlelweni lokwakhiwa kwempepho kuwumgogodla wokweqa imikhawulo yamanje yobuchwepheshe bokwenza impepho yokwenziwa kanye nokuxazulula inkinga yezinsiza zempepho unomphela.
Ukwakheka kwempepho empeleni kuwukuhlanganisa kancane kanye nokuqoqwa kwama-metabolites esibili avikelayo, ama-phenylethylchromones nama-sesquiterpenes, emzimbeni. Ama-phenylethyl chromones ahlukile kwimpepho futhi ayizinto eziyinhloko ezinomthwalo wemfanelo ekusebenzeni kwawo kanye nephunga elimnandi eliyingqayizivele. Ngokubambisana nezazi zaseNyuvesi yaseToyama kanye neNyuvesi yaseTokyo, ithimba lethu liye lathola indlela ye-biosynthetic ye-phenylethylchromone futhi lakha uhlelo lwe-biosynthetic lokuhlanganiswa okusheshayo kwe-phenylethylchromone eyahlukene ngokwesakhiwo kusetshenziswa amaseli amisiwe e-Melaleuca alternifolia. Imisebenzi yebhayoloji ye-in vivo ye-PECPS iboniswe ngokuvezwa kwesikhashana kwe-PECPS ku-C. benthamiana kanye ne-knockdown ye-PECPS ku-C. alba healing tissues. Izinhlaka zekristalu ze-PECPS kanye namaprotheni ayo amane abalulekile aguquguqukayo alungiswa futhi axazululwa, futhi indlela eyingqayizivele ye-PECPS ye-catalytic yacaciswa. Imiphumela yocwaningo oluyimpumelelo ezindabeni ezibalulekile zesayensi zokusebenzisa i-synthetic biology ukuze kuhlanganiswe izingxenye ze-phenylethylchromone zempepho kanye nokulawula ngokunembile ukwakheka kwephunga le-mullein emhlophe.
