I-Berberine (BBR), i-alkaloid yemvelo ye-isoquinoline ehlukanisiwe ne-Coptis chinensis, ibisetshenziswa kabanzi e-China ukwelapha izifo zamathumbu, ikakhulukazi i-bacterial gastroenteritis, izinkulungwane zeminyaka. Ucwaningo oluningi luphinde lwabonisa ukuthi i-BBR inomthelela ovikelayo kusistimu yezinzwa emaphakathi, ebonisa i-antidepressant, anxiolytic, kanye{1}}nemiphumela eqeda ukuvuvukala. I-BBR kubikwe ukuthi yehlisa ukudangala{3}}okufana nokukhathazeka{4}}njengokuziphatha ngokucindezela i-neuroinflammation kumagundane acindezelekile. Kolunye ucwaningo, kuphakanyiswe ukuthi i-BBR isebenzisa i-antidepressant-njengemiphumela kumagundane e-OVX ngokusebenzisa izindlela ze-BDNF-CREB kanye ne-eEF2.
I-gut microbiota ithathwa njengenhloso ethembisayo yokwelapha ukuphazamiseka kokukhathazeka. I-Berberine (BBR) ibonise ukusebenza kahle ekwelapheni i-postmenopausal osteoporosis, ukukhuluphala kanye nesifo sikashukela sohlobo 2 ngokushintsha i-gut microbiota. Nokho, umthelela we-BBR ekukhathazekeni kwangemva kokuya esikhathini uhlala ungacacile. Inhloso yalolu cwaningo bekuwukuhlola ukuthi i-BBR iyathuthukisa yini ukukhathazeka ngokushintsha i-gut microbiota ezimeni zokushoda kwe-estrogen. Ukukhathazeka kokuhlola kwasungulwa kumagundane athile e-pathogen-angenayo (SPF) ovariectomized (OVX), abe esephathwa nge-BBR amaviki angu-4 ngaphambi kokuhlolwa kokuziphatha. Ukuhlola{8}inkundla okuvulekile nokwezinga eliphezulu okuhlanganisa ne-maze kubonise ukuthi ukwelashwa kwe-BBR kuthuthukisa kakhulu ukukhathazeka{9}}njengokuziphatha kumagundane e-OVX uma kuqhathaniswa nozakwabo{10} abalashwayo emotweni. Ngaphezu kwalokho, amagundane e-BBR{12}}alapha e-OVX afukamele amagciwane azuzisa kakhulu amathumbu afana ne-Bacteroides, i-Bifidobacterium, i-Lactobacillus, ne-Arabidopsis, njengoba kuboniswa ukulandelana kwe-16S rRNA kanye ne-liquid chromatography/mass spectrometry (LC/MS) eveziwe yokuhlaziywa kokukhiqizwa kwe-Klebsiquella nokukhiqizwa. Ngokuphawulekayo, i-gavage ye-BBR ayizange ibe nemiphumela ebalulekile yokukhathazeka emagciwaneni ane-ovariectomized{15}}amahhala (GF), kuyilapho amagundane e-GF atshalwa kabusha nge-SPF rat fecal microbiota abonise ukukhathazeka okukhulu{16}}njengezimpawu namazinga e-isoflavone Ukuphindaphinda kwe-Phenotypic kumagundane anikelayo.
Lolu cwaningo lubonisa ukuthi i-gut microbiota ibalulekile ekulawulweni kwe-oophorectomy-ukukhathazeka okwedlulele kanye nokuthi ukushintshashintsha kwe-BBR kwe-gut microbiota kuyindlela yokwelapha ethembisayo yezimpawu zokukhathazeka zangemva kokuya esikhathini.
