I-Lycium barbarum yisithelo esomisiwe sesitshalo se-Solanaceae i-Lycium barbarum L., esinomlando weminyaka engaphezu kwe-2,000 yokusetshenziswa nokusetshenziswa kwezokwelapha. I-Wolfberry inothile ngama-flavonoids, okungase kube isizathu esiyinhloko somsebenzi ophezulu we-wolfberry, kodwa ucwaningo mayelana nokwakheka kwe-flavonoids ku-wolfberry namanje alwanele.
Ama-Flavonoid iqoqo elikhulu lezinto ze-polyhydric phenolic ezitholakala kakhulu-ekudleni okususelwe ezitshalweni okufana nemifino, izithelo kanye nokusanhlamvu. Lezi zinhlanganisela zinemisebenzi ehlukahlukene yezinto eziphilayo, njenge-antioxidant, i-antiviral, i-antitumor, imisebenzi ye-antibacterial kanye ne-hypolipidemic. Eminyakeni yamuva nje, umqondo wokukhuthaza impilo yabantu ngokungenela ukudla udonse ukunakwa okwengeziwe kwabacwaningi. Ngesikhathi esifanayo, imikhiqizo yemvelo isiphenduke isizinda socwaningo sokudla okunempilo kwabantu{4}}nezihloko ezihlobene nempilo ngenxa yezinzuzo zayo zemiphumela engemihle emincane, akukho ukumelana nezidakamizwa, kanye nenkomba yokuphepha okuphezulu. Kodwa-ke, ama-flavonoid esitshalweni{6}}ekudleni okukhiqizwa kunzima ukuwahlukanisa nokuwakhomba, okuvimbela ukusetshenziswa kwawo okuqhubekayo ekudleni okusebenzayo.
Ama-flavonoids (LBF) esithelweni se-Lycium barbarum kancane kancane asephenduke isizinda socwaningo ngenxa yemisebenzi yawo evelele ye-antioxidant, i-hypolipidemic, i-hypoglycemic, i-antitumor kanye ne-immunity{0}ethuthukisayo, kanye nemiphumela yawo yokuvimbela ezifweni zenhliziyo nemithambo yegazi. Njengamanje, ucwaningo lwama-LBF lugxile kakhulu ekukhishweni, ekuhlukaniseni nasekuhlanzweni, futhi izifundo ezimbalwa eziye zahlonza futhi zahlaziya izingxenye ezithile zama-LBF. Ngakho-ke, kuyadingeka ukucacisa ukwakheka okuhlanganisiwe kwama-LBF nokuhlola imisebenzi yawo yezinto eziphilayo.
Kulolu cwaningo, ama-flavonoid (LBFs) akhishiwe futhi ahlukaniswa ngaphambilini ku-Lycium barbarum L., kanye nama-flavonoid angu-13 ahlonzwe kusithelo se-Lycium barbarum nge-liquid chromatography{2}}i-mass spectrometry (LC{3}}MS). Phakathi kwazo, i-daphnetin, 6,7-i-dihydroxycoumarin, i-astragalin, i-taxifolin, i-eriodictyol, i-naringenin ne-chrysoeriol zitholwe kusukela kusithelo se-wolfberry okokuqala ngqa, okunothise izinhlobo ze-flavonoid esithelweni se-wolfberry. Umsebenzi we-antioxidant wama-LBF wacwaningwa ngokuhlolwa kwe-in vitro, futhi imiphumela yabonisa ukuthi ama-LBF ayenomsebenzi ofanayo we-antioxidant ku-VC. Ngesikhathi esifanayo, umsebenzi wokulwa{14}nokuvuvukala wama-LBF wacwaningwa kusetshenziswa imodeli yokuvuvukala ye-RAW264.7 macrophages edalwe yi-lipopolysaccharide (LPS). ukukhiqizwa kwe-IL-1 ne-IL-6), futhi kuvimbele ngokuphawulekayo ukuvezwa kwe-TNF- , IL-1 ne-IL-6 ezingeni le-mRNA. Imiphumela ibaluleke kakhulu ekucebiseni izinhlobo ze-flavonoid esithelweni se-Lycium barbarum kanye nokusetshenziswa okunamandla kwama-LBF njengokudla okusebenzayo.
