Inganweba isikhathi sempilo ye-Caenorhabditis elegans
Uma kukhulunywa ngokuncipha kwesisindo se-chlorogenic acid, abanye abantu bangase bajwayele. I-Chlorogenic acid inezinhlobonhlobo zemisebenzi yebhayoloji, futhi ucwaningo lwesayensi lwesimanje ngemisebenzi yalo yezinto eziphilayo lungene emikhakheni eminingi efana nokudla, ukunakekelwa kwezempilo, imithi kanye nemboni yamakhemikhali yansuku zonke.
I-Chlorogenic acid ikhona enanini elikhulu lezitshalo, njengetiye, ikhofi, i-honeysuckle, njll. Ingenye yezithako ezisebenzayo zokulwa namagciwane kanye ne-antiviral pharmacological emithini eminingi yama-herbal yaseShayina nemikhiqizo yemvelo. Ocwaningweni lwangaphambilini lwesayensi, abacwaningi bathole ukuthi isithasiselo se-chlorogenic acid sinemiphumela eminingi efana ne-antibacterial, antiviral, ukuthuthukiswa kwamangqamuzana egazi amhlophe, ukuvikela isibindi kanye ne-choleretic, -isimila, ukwehlisa umfutho wegazi, ukwehlisa i-lipids egazini, ukukhipha ama-free radicals, kanye nesistimu yezinzwa ejabulisayo{3}} Nokho, umthelela kanye nendlela yokuguga kwe-chlorogenic bekulokhu kucacile.
"Itiye nekhofi yiziphuzo zansuku zonke ezisetshenziswa kakhulu emhlabeni. Abantu benze ucwaningo olunzulu mayelana nokusebenza komzimba walezi zinto ezimbili. Senze ucwaningo lwezincwadi futhi sathola ukuthi ingxenye evamile yetiye nekhofi, i-chlorogenic acid etiyeni, inemiphumela eqeda ukuvuvukala, -inomthelela wokuvimbela ukuguga{3}}ezifweni ezihlobene. Ngakho-ke, {5}singaba nomphumela we-chlorogenic{5}ukuthi singaba nomphumela wokuthi "i-chlorogenic" ULuo Huairong etshela intatheli yeChina Science Daily.
Ithimba locwaningo lika-Luo Huairong laqala ukusebenzisa i-Caenorhabditis elegans njengemodeli ukuze lihlole{0}}imithelela yokuguga ye-chlorogenic acid kanye nendlela yayo. "I-Caenorhabditis elegans iyinhlangano eyisibonelo socwaningo lokuguga. Inesikhathi esifushane sokuphila se-2 kuphela kumaviki angu-3. Inomsebenzi ocacile wezinto eziphilayo kanye nesizinda sofuzo. Kunezinhlobo eziningi ze-genetic mutant ezingasetshenziswa, futhi kulula ukwenza ukuhlaziywa kokulawulwa kwesignali ye-physiological ezingeni lezilwane jikelele." Mayelana nokusetshenziswa kwe-Caenorhabditis elegans njengemodeli, uLuo Huairong wachaza.
Ngemva kocwaningo oluhlelekile, okutholwe yithimba lika-Luo Huairong kuqinisekise ukuqagela kwangempela kokuthi i-chlorogenic acid ekhofini eliluhlaza inganweba isikhathi sokuphila-sohlobo C. elegans ngo-20.1%.
umphumela wokubikezela kubantu
Ingabe i-chlorogenic acid iwufinyelela kanjani lo mphumela wokulwa-nokuguga? Iqembu locwaningo lika-Luo Huairong lithole ukuthi i-chlorogenic acid ingakwazi ukusebenza endleleni yokubonisa i-insulin, yehlise izinga le-phosphorylation ye-AKT, isebenze ukuvezwa kwe-transcription factor DAF-16 kanye nezakhi zayo zofuzo ezansi nomfula, futhi yandise ukumelana kwe-nematodes ezindaweni ezicindezelayo zangaphandle, ngaleyo ndlela yandise isikhathi sokuphila se-nematode.
Ufuzo lwe-DAF-16 luyisilawuli sesikhathi sokuphila. Ucwaningo lwangaphambilini olwenziwa ososayensi ngezikelemu zaselabhorethri lubonise ukuthi isakhi sofuzo se-DAF-16 sihlobene kakhulu nokuphila isikhathi eside kanye nokugonywa komzimba.
Ngokuka-Luo Huairong, ukuguga komuntu kubonakala ngokulahlekelwa kancane kancane kobuqotho bokuphila, okuholela ekusebenzeni okonakalayo kanye nokwanda kokuba sengozini, futhi ekugcineni kuholele ekufeni. Lokhu kuwohloka kuyisifo esikhulu sabantu, okuhlanganisa izici eziyingozi ezinkulu zomdlavuza, isifo sikashukela, isifo senhliziyo nemithambo yegazi, kanye nezifo ze-neurodeergenerative.
"Eminyakeni yamuva nje, ucwaningo lokuguga luye lwabhekana nenqubekela phambili engakaze ibonwe ngaphambili, ikakhulukazi ukutholakala ukuthi izinga lokuguga liyalawuleka, futhi izindlela zofuzo kanye nezinqubo ze-biochemical zokuguga zilondoloza ekuziphendukeleni kwemvelo." U-Luo Huairong uthe ukuguga kwezinto eziphilayo ezihlukahlukene kunezimpawu ezivamile. Izici zocansi, njengokungaqini kofuzo, ukuncipha kwe-telomere, izinguquko ze-epigenetic, ukulahlekelwa amaprotheni e-homeostasis, ukungeniswa kokudla okunomsoco, ukungasebenzi kahle kwe-mitochondrial, ukuqina kwamangqamuzana, ukuncipha kwamangqamuzana e-stem, izinguquko ekuxhumaneni kwe-intercellular, njll umzimba ngesikhathi senqubo yokuguga ngemiphumela emibi emincane.
Ngakho-ke, iqembu locwaningo lwe-Luo Huairong lizibophezele ekusebenziseni imodeli yesilwane C. elegans ukufunda indlela yokuguga, nokusebenzisa amaseli namamodeli we-nematode ukuze kuthuthukiswe{1}}izidakamizwa zokuguga. Ucwaningo olumayelana{3}}nemiphumela yokuguga nezindlela ze-chlorogenic acid lungolunye lwazo. Okwamanje, ithimba lika-Luo Huairong lihlole ngempumelelo inqwaba yezinhlanganisela ezinemiphumela elwa{5}}nokuguga, futhi lifunda indlela yokusebenza kwalo ngokujulile.
I-Chlorogenic acid ingandisa isikhathi sokuphila se-Caenorhabditis elegans. Ingabe lokhu kusho ukuthi kuzoba nomthelela osebenzayo ekulweni{1}}nokuguga kwabantu? Ngokuphathelene nalokhu, uLuo Huairong wachaza ukuthi ngenxa yokuthi indlela yokuguga manje ibhekwa njengelondoloza kakhulu, okungukuthi, ukulawulwa kwezibonakaliso zokuguga phakathi kwezinhlobo ezahlukene ezifana nemvubelo, i-nematodes, izimpukane zezithelo, amagundane, nezinkawu ziyafana. Ngakho-ke, imiphumela yocwaningo kuma-nematode inomphumela omuhle wokubikezela kubantu. "Yebo, umphumela wangempela ungaqinisekiswa kuphela ngokuhlolwa komtholampilo okuqinile."
