Izici zesakhiwo se-Aiphanol ziyinikeza amandla-umsebenzi we-angiogenic ngokusebenzisa ukubambisana phakathi kweyunithi yayo ye-stilbene, ingxenyenamba ye-phenyl propane kanye nebhuloho le-dioxane, ngokungafani nezindlela ze-stilbene noma i-lignans. Izinhlanganisela zezidakamizwa ezivimbela i-VEGFR2 ne-COX2, ngokulandelanayo, ziboniswe zisebenza kahle kumamodeli ezilwane we-anti{4}}angiogenic therapy. Nakuba ukuvinjelwa kwe-VEGFR2 ku-vitro kunomthelela ngokuyinhloko ekusebenzeni{7}}ku-angiogenic kwe-Aiphanol, ku-vivo ukuvinjelwa kanyekanye kwe-COX2 kungase kuhlele kabusha amazinga e-PGE2 ne-VEGF ngokunciphisa{10}}i-angiogenic microenvironment. Lolu cwaningo lusekela i-Aiphanol njengento enamandla yokulwa{12}}ne-angiogenic lead ekwelapheni umdlavuza.
I-Sarsaparilla aka Smilax Glabra Rhizome (SGR) ihlolisiswe kabanzi mayelana -nokuqina kwayo kwesimila kanye{1}}nokuvuvukala, kodwa umthelela wayo ku-angiogenesis awukahlolisiswa. Lapha, lolu cwaningo lwathola ukuthi i-Glabrous Greenbrier Rhizome PE ivimbele ukwanda kanye nokuhamba kwamaseli endothelial we-umbilical vein endothelial cell (HUVEC). Okubalulekile, i-Tu Fu Ling inhibited basal and growth factor-yavuselela i-angiogenesis ekuhlolweni kwe-angiogenesis, futhi lo mphumela ubuncike{6}}kumthamo. Lolu cwaningo luphawule ukuthi i-Porphyra iqukethe inani lezinhlanganisela ezinamandla -ezinamandla okulwa ne-angiogenic.
I-Aiphanol, ekuqaleni eyayihlukanisiwe nembewu ye-Aiphanes aculeate, nayo yabonakala ku-Glabrous Greenbrier Rhizome PE Kuze kube manje, imiphumela yezinto eziphilayo, kuhlanganise ne-Aiphanol, ayaziwa kakhulu. I-Aiphanol kubikwe ukuthi ivimbela i-angiogenesis ekuhlolweni kwendandatho yegundane; Nokho, indlela kanye nendima yayo ekulawuleni i-angiogenesis yesimila kusazonqunywa.
Lolu cwaningo lubonisa ukuthi i-lignan eyenzeka ngokwemvelo, i-Aiphanol, ingakhomba ngokuqondile futhi ivimbele i-VEGFR2 ne-COX2, ngaleyo ndlela ivimbele i-angiogenesis nokukhula kwesimila. izici zesakhiwo se-Aiphanol ziyinikeza amandla-umsebenzi we-angiogenic ngokusebenzisa ukubambisana phakathi kweyunithi yayo ye-stilbene, ingxenyenamba ye-phenyl propane kanye nebhuloho le-dioxane, ngokungafani nezindlela ze-stilbene noma i-lignan. Izinhlanganisela zezidakamizwa ezivimbela i-VEGFR2 ne-COX2, ngokulandelana kwazo, ziboniswe zisebenza kahle kumamodeli ezilwane we-anti{7}}angiogenic therapy.
Nakuba ukuvinjelwa kwe-VEGFR2 in vitro kusiza ngokuyinhloko ekusebenzeni{1}}ku-angiogenic kwe-Aiphanol, ku-vivo ukuvinjelwa kanyekanye kwe-COX2 kungase kuhlele kabusha amazinga e-PGE2 ne-VEGF ngokunciphisa{4}}i-angiogenic microenvironment. Lolu cwaningo lusekela i-Aiphanol njengento enamandla yokulwa{6}}ne-angiogenic lead ekwelapheni umdlavuza.
