I-Morinda officinalis oligosaccharide (MOO) iyisidakamizwa esithathwa ngomlomo esigunyazwe e-China ukwelapha ukudangala. Kodwa-ke, i-MOO ayimuncwe neze, ngakho-ke indlela yayo ye-antidepressant ayikacaciswanga. Lapha, sibonisa ukuthi i-Oral MOO isebenza ku-tryptophan→5-hydroxytryptophan (5-HTP)→serotonin (5-HT) indlela ye-metabolic ku-gut microbiota. I-MOO ingakhuphula izinga le-tryptophan hydroxylase ku-gut microbiota, ngaleyo ndlela isheshise ukukhiqizwa kwe-5-HTP kusuka ku-tryptophan; ngesikhathi esifanayo, i-MOO ivimbela umsebenzi we-5-hydroxytryptophan decarboxylase, ngaleyo ndlela inciphisa ukukhiqizwa kwe-5-HT nokunciphisa ukukhiqizwa kwe-5-HT. Ukuqoqwa kwe-5-HTP. I-5-HTP ephakeme ku-gut microbiota idonswa egazini bese yeqa umgoqo wegazi nobuchopho ukuze kwandiswe amazinga angu-5-HT ebuchosheni. Ngaphezu kwalokho, i-pentasaccharide, njengenye yezingxenye eziyinhloko ku-MOO, yenza umphumela obalulekile wokuqeda ukucindezeleka ngendlela efanayo ne-MOO. Lolu cwaningo lungokokuqala ukuveza ukuthi i-MOO inganciphisa ukucindezeleka ngokwandisa i-5-HTP ku-gut microbiota.
Ukucindezeleka yisifo sengqondo esivamile esithinta abantu abangaphezu kwezigidi ezingu-264 emhlabeni jikelele. Nokho, ukwelapha kwamanje ukucindezeleka akugculisi ngenxa yezizathu ezihlukahlukene, njengokuntuleka kwemithi yokwelapha ephumelelayo; ngakho-ke, kufiseleka kakhulu ukuthola ezinye izindlela zokwelapha ezinhle.
I-Morinda officinalis (MO) ingeminye yemithi emine yamaShayina edumile eningizimu. U-MO, oyilungu lomndeni wakwaRubiaceae, ungesinye sezitshalo ezidume kakhulu eningizimu yeChina futhi sisetshenziswa njengomuthi wamakhambi aseShayina. I-Morinda officinalis oligosaccharide (MOO, Umfanekiso 1a) iyisithako esisebenzayo esikhishwe ezimpandeni ze-MO. I-MOO iyingxube yama-oligosaccharides asuka ku-trisaccharides kuya{4}}okungewona ama-monosaccharides, ikakhulukazi akhiwe izinhlobo ezingu-7 zama-oligosaccharides, anemiphumela yezokwelapha ye-antidepressant, antidementia kanye nokuthuthukisa inkumbulo. I-MOO igunyazwe njengemithi elwa nokucindezeleka kadokotela e-China ngo-2012 (inombolo yokugunyaza ye-NMPA: Z20120013), iba umuthi wendabuko wase-Chinese (TCM) wokwelapha ukudangala. Imiphumela yocwaningo lomtholampilo lwesigaba I olwenziwa e-China yabonisa ukuthi ngemva kokuthatha amaphilisi e-MOO, wonke amavolontiya anempilo kulolu cwaningo abonise ukubekezelelana okuhle, futhi iqembu ngalinye le-MOO lanikezwa umthamo owodwa (50-}1000mg) noma ngokuqhubekayo izinsuku ezingu-7 (800mg/ngosuku). Okuwukuphela kwemiphumela engemihle eyabonwa kwaba ukozela, ukukhathala nomlomo owomile. Imiphumela yokuhlolwa komtholampilo kwesigaba II-III ibonise ukuthi awukho umehluko wezibalo ezenzakalweni zokusabela okubi phakathi kweqembu lokwelapha izidakamizwa neqembu le-placebo kumthamo wokwelapha (300 noma 600 mg/ngosuku). Ngaphezu kwalokho, amaphilisi e-MOO awasebenzi kangako kune-fluoxetine yokucindezeleka.
Eminyakeni edlule, sihlole izindlela zamangqamuzana zama-antidepressants ngokutadisha i-gut microbiome. Okulandelayo indlela yamangqamuzana lapho i-MOO ithuthukisa khona izimpawu ezivimbelayo. Lokhu kungase kunikeze isibonelo esisha semishini se-"gastric{2}}brain axis" exhunywe ngamakhemikhali ye-5-THP, nemithelela ebanzi yokusetshenziswa kwemithi yemvelo okunzima ukuyimunca amathumbu.
1. I-MOO ingakhuphula izinga le-5-HTP emilanjeni yamathumbu futhi inciphise ukukhiqizwa kwe-5-HT in vitro.
2. Ukwelashwa kwe-MOO kuthuthukise ukuziphatha okucindezelayo futhi kwashintsha amazinga angu-5-HTP kanye ne-5-HT endle, egazini, nasengqondweni kumagundane e-CUMS namagundane enziwe i-reserpine.
3. I-MOO ishintsha amazinga e-TPH, BH4, VB6 kanye nomsebenzi we-5-HTPDC ku-vitro.
4. Ukuhlolwa komthelela we-antidepressant we-MOO ukusuka ku-trisaccharide ukuya{1}}okungeyona i-monosaccharide in vitro, nokuqinisekiswa komsebenzi we-enzymatic we-TPH kanye ne-5-HTPDC ezimila zamathumbu.
I-5.PSA ibonise imiphumela efanayo ku-gut microbiota in vitro uma iqhathaniswa ne-MOO.
6. Isixhumanisi esingaba khona phakathi kwe-MOO nezinhlobo ezithile ze-gut microbiota ekucindezelekeni.
Ihlanganiswe ndawonye, i-MOO inemiphumela eqeda ukucindezeleka ngokulawula 5-i-HT synthesis ku-gut microbiota. I-MOO iqale yandisa izinga le-TPH, ngaleyo ndlela ikhuthaza ukuguqulwa kwe-Trp kuya ku-5-HTP; okwesibili, i-MOO yehlisa umsebenzi we-5-HTPDC emilanjeni yamathumbu, ngaleyo ndlela ivimbele ukuhunyushwa kwe-5-HTP kuya ku-5-HT. Imiphumela yabonisa ukuthi ukuhlanganiswa kwe-5-HTP emilanjeni yamathumbu kwanda futhi i-metabolism ye-5-HT yehla, ngaleyo ndlela kwandisa kakhulu ukumuncwa kwe-5-HTP egazini. Njengoba i-5-HT egazini, kodwa i-5-HTP ayikwazi ukungena ebuchosheni ngokusebenzisa umgoqo wegazi-ubuchopho37,63, ukwanda kwe-5-HTP egazini kungase kungene ebuchosheni, kuqhubekisele phambili ukukhuthaza ukukhiqizwa kwe-5-HT, futhi kube nomphumela we-antidepressant.
