Isifo sesibindi esingeyona-i-alcoholic fatty liver (NAFLD) yisifo sesibindi esingalapheki esivame kakhulu, futhi kusenokuntuleka kwemithi yokwelapha esebenzayo. Inani elikhulu locwaningo libonise ukuthi ukuphazamiseka kwezitshalo zamathumbu kuyisici esibalulekile ku-pathogenesis yokukhuluphala{2}izifo ezisuselwa ku-metabolic. Ngakho-ke, ukuqondisa ukulawulwa kwezitshalo zamathumbu kubhekwa njengesu elisha elibalulekile lokuvimbela nokwelashwa kwezifo ze-metabolic. I-Polysaccharides iyikilasi lama-macromolecular compounds emvelo asatshalaliswa kabanzi emithini yendabuko yaseShayina. Inani elikhulu lezifundo libonise ukuthi i-polysaccharides yezitshalo inemiphumela ecacile ekulawuleni umzimba we-metabolism, kodwa indlela eqondile ayicacile ngokuphelele.
Ithimba likaProf. Houkai Li liqinisekise ocwaningweni lwangaphambilini ukuthi ingxenye eyinhloko esebenzayo ye-Qi{1}}ethuthukisa imithi yendabuko yamaShayina i-Astragalus, i-astragalus polysaccharide, inomthelela wokuthuthukisa ukukhuluphala kanye ne-NAFLD, futhi ngokusebenzisa i-metagenomic ehlanganiswe{2}}nokuhlaziywa kwe-metabolomics engahlosiwe, kwaqashelwa ukuthi i-Astratestinal i-polysacc yeharibindi. Umphumela olawulayo we-microbiota kanye ne-microbiota metabolites uphakamise "isidakamizwa-i-gut microbiota-i-microbiota metabolite-i-host metabolism" i-axis hypothesis yobudlelwano yokuthi i-astragalus polysaccharides ithuthukisa ukwakheka kwe-NAFLD. Ngokusekelwe kulo mbono wesayensi, ithimba locwaningo lihlole amagciwane athile amathumbu kanye nama-metabolites ahlobene alawulwa i-astragalus polysaccharides ngokusebenzisa-isu elihlanganisiwe le-omics. I-Gut bacteria, i-Desulfovibrio vulgaris. Olunye ucwaningo lwaqinisekisa ukuthi ibhaktheriya aliyona kuphela i-H2S yemvelo-ekhiqiza ibhaktheriya, kodwa futhi inamandla okukhiqiza i-acetic esebenza kahle kakhulu. Ukwengezwa kwangaphandle kwaleli bhaktheriya kungathuthukisa kakhulu isibindi se-steatosis, ukuzwela kwe-insulin kanye nokuzuza kwesisindo{14}}ekudleni okunamafutha{15}okukhulu amagundane. Ukuhlaziywa kwesibindi se-RNA seq kanye nezifundo ze-molecular biology kuqinisekisile ukuthi ukuthuthukiswa kwe-NAFLD kwakuhlobene nokuvinjelwa kwesibindi se-FASN kanye ne-CD36 protein expression. Lolu cwaningo luhlinzeka ngobufakazi obusha bokuchaza indlela ye-astragalus polysaccharides ekuthuthukiseni i-NAFLD, futhi ihlinzeka ngereferensi yokuhlola indlela yama-polysaccharides ezitshalo alawula ukumila kwamathumbu nokuthuthukisa i-metabolism yosokhaya ngokusebenzisa{19}}ubuchwepheshe be-omics.
