Umnotho wokulala mkhulu futhi ukhula kancane kancane. Ngokusho kwedatha evela ku-iResearch, kusukela ngo-2016 kuya ku-2020, usayizi wemakethe jikelele womnotho wokulala waseChina ukhule usuka ku-261.63 wamayuan ayizigidi eziyizinkulungwane ezingu-377.86, kanye nezinga lokukhula elihlanganisiwe lonyaka elicishe libe ngu-9.6%. ifinyelele ku-570.7 billion yuan.
Ukufingqa, imithi kanye nemikhiqizo yokunakekelwa kwezempilo emnothweni wokulala ingeyemakethe yolwandle eluhlaza okwesibhakabhaka enamathemba okukhula okuthize uma kuqhathaniswa, futhi kulindeleke ukuthi izuze okwengeziwe esidingweni esikhulayo sokulala sabantu baseChina.
Ngokwedatha yenhlolovo ye-iiMedia Research, ngo-2021, u-45.3% wabasebenzisi benethiwekhi e-China bathenge izinsiza zokulala ezisekelwe kuvithamini-, u-29.5% wabasebenzisi benethiwekhi bathenge izinsiza zokulala ze-melatonin, ngaphezu kwemithi ekhishwe ngamakhambi, i-niacinamide mononuclear Glycine kanye ne-glycine njengezinsiza zokulala ezingu-29, 5% kanye no-12%. yabathengi ngokulandelana.
Abathengi abaningi ngokwengeziwe bafuna izithasiselo zokudla ezizobasiza ngezinkinga zokulala, kuyilapho abathengi bekhetha imikhiqizo eyengeziwe yemvelo nenempilo futhi bagwema izidakamizwa.
Izinsiza zokulala ze-amino acid zihlanganisa i-glycine, i-serine, L-tryptophan, arginine, ornithine, ne-5-hydroxytryptophan.
Ucwaningo luye lwathola ukuthi i-milk hydrolyzate "casein hydrolyzed peptides" iyisisombululo esiyingqayizivele, esingokwemvelo futhi esisheshayo nesisebenzayo sokusiza abantu ukukhulula izimpawu ezihlukahlukene ezibangelwa ukucindezeleka. Kugunyazwe i-French Agency for Safety Control and Supervision (DGCCRE*) ukuze kunikezwe isitifiketi sezempilo futhi kugunyazwe njengesithako sokudla yi-French Food Safety Agency (AFSSA*).
Phakathi kwezitshalo zokusetshenziswa kwemithi yemithi yamaShayina, i-saffron extract, i-jujube seed extract, i-apocynum extract, i-ganoderma extract, i-lily extract, i-tuckahoe extract, i-longan extract, i-Bupleurum, i-ginger ekhishwe omisiwe, i-Scutellaria baicalensis ekhishwe usizo Ukuthobisa izinzwa nokusiza ukulala.
Imbewu yeJujube iqukethe izakhi ezihlukahlukene zemithi ezifana ne-alkaloids, saponins nama-flavonoids. Ine-sedative, hypnotic, analgesic, anticonvulsant kanye neminye imiphumela, phakathi kwayo i-spinosin ne-jujube seed saponin A izingxenye eziyinhloko zomsebenzi wokulalisa kanye nokulutha kwembewu yejujube. Uma kuqhathaniswa ne-chemical sedative-hypnotics, izithako ezisebenzayo ze-Suanzaoren zinezici zokuhloswe ngazo eziningi, izitho ezisebenzayo eziningi, kanye nemiphumela encane.
I-Hypericin ne-isoquerctrin ekukhishweni kwe-Apocynum zingathuthukisa ukulala. Ngesikhathi esifanayo, ukukhishwa kwe-apocynum kuhlanganiswe ne-GABA nakho kusiza ukukhulula ukucindezeleka.
I-Theanine iyi-amino acid eyingqayizivele ekhona etiyeni, enye yezingxenye eziyinhloko zetiye, ibalwa ku-50% -60% wengqikithi yama-amino acid etiyeni. Ngokocwaningo, ukuthatha i-theanine kusebenza kahle kubantu abanokuphazamiseka kokulala okuncane kuya kokulinganisela. Kuyasiza ukungena ebuthongweni obujulile, okungalungisa kangcono ukukhathala komzimba.
I-GABA (i-gamma-i-aminobutyric acid) ayiyona{1}}iphrotheni amino acid eyenzeka ngokwemvelo kanye ne-neurotransmitter ebalulekile. Ingapholisa ingqondo nomzimba futhi ikhuthaze ukulala nge-neuromodulation. Ucwaningo luye lwabonisa ukuthi lunemiphumela yokuzinza, i-anticonvulsant, ukwehlisa umfutho wegazi, ukuthuthukisa ubungqabavu bezinzwa zamangqamuzana, ukukhuthaza i-hormone yokukhula, ukuvikela isibindi nezinso, njll. Ngo-2009, yaqashelwa njengokudla okusha kwensiza nguMnyango Wezempilo waseShayina.
Phakathi kwezitshalo zemvelo, i-valerian extract, i-passionflower extract, amaqabunga e-lemon balm, i-chamomile extract, i-chamomile ekhishwe, i-lemon balm extract, i-asparagus extract, i-tart cherry extract, i-garlic ekhishwe endala ( Izithako zenkomba: S-i-allyl cysteine, i-arginine), i-spearmint extract, njll. inomthelela wokusiza ukulala.
Izithako ezithuthukayo{{0}ezisekelwe kumaprotheni{1}}zihlanganisa i-whey protein (equkethe i-lactalbumin) ne-lactoferrin.
I-Alpha-whey protein inganikeza inhlanganisela engcono kakhulu yama-amino acid futhi ithuthukise i-bioavailability yamaprotheni. Icebile ku-tryptophan, okuyisandulela se-neurotransmitters serotonin ne-melatonin, ekhishwa ngokuhlukile ngamaseli e-pineal: I-Serotonin ikhishwa phakathi nosuku, okuyi-neurotransmitter elawula isimo sengqondo, isifiso sokudla nokuziphatha; I-melatonin ikhiqizwa ebusuku, okuyi-endo native sleep inducer kanye nesilawuli esibalulekile sewashi lebhayoloji yangaphakathi, esiza izinsana zilale.
I-Lactoferrin iyingxenye yemvelo ecebile obisini lwebele, ibalwa cishe ngama-20% wengqikithi yamaprotheni obisini lomuntu. Ucwaningo olushicilelwe ku-Japanese Pharmacology and Therapeutics lubonise ukuthi amaviki angu-4 e-lactoferrin supplementation athuthukisa ukulala okuzimele nokukhathala lapho uvuka, ikhwalithi yokulala ebusuku, isimo sengqondo sokucindezeleka nsuku zonke, nendawo yamathumbu.
Izithako zamakhemikhali zokuthuthukisa ukulala zihlanganisa i-5-aminolevulinic acid phosphate ne-melatonin.
I-5-i-aminolevulinic acid phosphate ingase ithuthukise ukulala, ucwaningo lweqembu oluyizimpumputhe oluphindwe kabili, olungahleliwe olushicilelwe ku-International Journal of Clinical Medicine, izifundo ezingu-40 ezinezinkinga zokulala zahlukaniswa ngamaqembu amabili, zithole i-placebo kanye ne-50mg ye-5-ALA, imiphumela yabonisa ukuthi ukulala kweqembu elithatha i-5-ALA kwathuthukiswa kakhulu.
I-Melatonin iyi-hormone ekhiqizwa indlala ye-pineal ebuchosheni elawula amanye amahomoni emzimbeni kanye newashi lebhayoloji yomzimba. Lapho umzimba womuntu ungena endaweni emnyama, ubuchopho buqala ukukhiqiza i-melatonin eyengeziwe; ngemva kokungena endaweni ekhanyayo, umzimba uqala ukuphula i-melatonin futhi. I-Melatonin iyatholakala njengesengezo sokudla, futhi ucwaningo luye lwabonisa ukuthi ingasiza ngokulala okuvamile.
Ukwenziwa kusebenze kwama-adenosine A2a receptors kuma-neuron obuchopho kubangela ukulala ezilwaneni ezincelisayo ezihlukahlukene. Ucwaningo lwangaphambilini luthole ukuthi i-Sake yeast yenza kusebenze isamukeli se-A2a kumaseli e-HEK futhi idala ukulala kumagundane nge-EC50 ye-40 ug·mL(-1) ngendlela encike kumthamo.
Ngokuhlelwa kwedatha nezibalo, kuphetha ngokuthi izinto zokusetshenziswa ezinemvamisa ephezulu yokulala-okuthuthukisa ukudla kwezempilo yi-Suanzao Ren (izikhathi ezingu-276), i-melatonin (izikhathi ezingu-167), i-Schisandra chinensis (izikhathi ezingu-105), i-Poria (izikhathi ezingu-99), i-Ganoderma lucidum (izikhathi ezingu-81)), i-Acanthopananse (76), i-Girl64), i-Girl64), i-Girl64), i-Girl6, i-Girl6 (52), Polygalaceae (51), Lily (50 izikhathi), Goji berry (39 izikhathi), Baiziren (34 izikhathi), Angelica (32 izikhathi), Astragalus (30 izikhathi), Honey (29 izikhathi), Jujube (28 izikhathi), Shouwu Teng (26 izikhathi), Ganoderma lucidum spore powder (21 izikhathi lactiflora), Paaonia izikhathi 21), Paaonia lactiflora (izikhathi ezingu-21). Phakathi kwezinto ezisetshenziswayo eziphezulu ezingu-20 ngokwezikhathi zokusetshenziswa, zonke ngaphandle kwe-melatonin imithi yesiShayina noma izithako zayo, okubonisa ukuthi izinto zokwelapha zaseShayina ziseyizingxenye ezibaluleke kakhulu zokulala{23}}ezithuthukisa ukudla kwezempilo ezweni lami.
