I-Red clover isitshalo esingapheli esitholakala eYurophu, e-United States naseNew Zealand. I-clover ebomvu ngokwesiko ibibhekwa njenge-antispasmodic yokuphefumula. Umthelela we-estrogenic wezinhlobo ze-red clover wabonwa ngesikhathi sokufuywa, futhi ngemva kocwaningo, kwatholakala imiphumela ehlobene ne-isoflavonoid{2}}ye-red clover, ekhuthaze ukuthuthukiswa nokudayiswa kwezithako zokudla ezivela esitshalweni se-clover ebomvu.
I-clover ebomvu inothile ngama-isoflavone, ama-flavonoid nama-flavonol, okuyi-isoflavones okuyiwo ayingxenye ethinteka kakhulu yokusebenza ngempumelelo. Ama-isoflavone ezitshalo acishe akhiqizwe ngokuphelele ku-legumes, futhi evame kakhulu ama-soy isoflavones.
Uma kuqhathaniswa ne-soy isoflavone, ukwakheka kwe-monomeric ye-isoflavone ye-clover ebomvu kubonakala kubanzi, i-prickly mangosteen ne-chickpea A (uhlobo lwe-isoflavone) iphakeme kune-soy isoflavones, kuyilapho okuqukethwe kwe-luteolin ne-genistein kuphansi. Ngaleso sikhathi, ama-isoflavone e-clover ebomvu ngokuyisisekelo awanawo amaprotheni, aphinde agweme ukungezwani komzimba ngesikhathi sokusetshenziswa okusebenzayo.
I-Estrogen idlala indima ebalulekile kwabesifazane kuyo yonke iminyaka, futhi phakathi nenkathi yokunqamuka kokuya esikhathini, ukwehla kwe-estrogen, ikakhulukazi 17 -}i-estradiol, kuveza izimpawu ezihlukahlukene zokuya esikhathini njengokulahlekelwa kwamathambo, ukushisa okushisa, kanye nokuphazamiseka kwe-metabolic okuhambisana ne-blood lipids noma umfutho wegazi, futhi ukushintshwa kwe-phytoestrogen kuba inketho enhle yokunakekelwa okunempilo.
Ama-Phytoestrogens ama-metabolite esibili adala ukusabela kwebhayoloji ezilwaneni ezinomgogodla futhi angalingisa noma alungise imiphumela yama-estrogen angapheli, ngokuvamile ngokubophezela kuma-estrogen receptors (ERs).
Ama-ER ama-steroid receptors futhi ama-ER aqukethe izinhlobo ezimbili ezincane ER kanye ne-ER kulwelwesi lweseli, afana nama-steroidal estrogens omzimba. I-ER idlala indima ebalulekile yokulawula kumetabolism yamathambo omzimba, kuyilapho izicubu zebele nesibeletho zithonywa ama-ER estrogens, ngaleyo ndlela ukusatshalaliswa okuhlukile kwama-estrogen receptors kunikeza ithuba lokukhomba izicubu ezithile.
Ama-isoflavone e-clover ebomvu ayafana ngesakhiwo ne-endogenous 17 -estradiol, enokusondelana okuphezulu kwe-ER- uma kuqhathaniswa ne-ER- . Ngaphezu kwalokho, imithelela embalwa engeyona{3}}ye-hormonal ye-isoflavone ibikiwe, okuhlanganisa ukuvinjelwa kwe-tyrosine kinases, umsebenzi we-antioxidant kanye nemiphumela ekuthuthweni kwe-ion.
I-United Nations World Health Organization ilinganisela ukuthi kuzoba nezigidigidi ezingu-1.2 zokunqamuka kokuya esikhathini noma{1}}kwabesifazane abanqamuka kokuya esikhathini emhlabeni wonke ngo-2030, futhi imakethe yomhlaba wonke yokondleka kwabesifazane abanezimpawu zokunqamuka kokuya esikhathini kulindeleke ukuthi idlule ku-$50 billion ngo-2025, ikhula ku-CAGR ka-16.4% kusukela ngo-2016-202020202.
Izithako ezisezingeni eliphezulu-zokusetshenziswa kokudla i-soy isoflavones, i-estradiol, i-clover ebomvu, ne-black asclepias extract, kodwa e-China abantu basebenzisa isoya isoflavone eningi futhi bahlanganisa izithako zokwelapha zendabuko, njenge-angelica ne-Pueraria Mirifica.
Ngokusho kweGlobal information, Inc. inhlolovo, imakethe yomhlaba wonke ye-isoflavones izofinyelela ku-$ 1.3 billion ngo-2020 futhi kulindeleke ukuthi igcine i-CAGR engu-4.7%, ikakhulukazi ezimakethe zokudla kanye nezimakethe ze-cosmeceutical.
Futhi i-DATAINTELO ilindele ukuthi imakethe ye-clover ebomvu yomhlaba wonke ikhule ngenani elingu-13.7% ukusuka ngo-2020-2026, idlule ukukhula kwemakethe ye-isoflavones, okubonisa ukuthi ukukhula kwama-isoflavones abomvu kushayela imakethe ye-isoflavones yomhlaba wonke, nokukhula kwayo okubangelwa impilo yayo yezempilo kanye nezinjongo zezokwelapha.
Ama-isoflavone abomvu e-clover asetshenziswe isikhathi eside eYurophu nase-United States, kodwa ngenxa yezizathu zendawo kanye nokulawula, awasetshenziswa kakhulu e-China futhi asesiteji esikhulayo. Kodwa-ke, ukubunjwa kwayo kufana nalokho kwe-soy isoflavones, futhi ububanzi bokusebenza kwayo bukhulu kakhulu, obungahlinzeka abaklami bemikhiqizo ngezinketho ezihlukene kakhulu.
