I-OPC-I-B2 iyinhlanganisela ye-polyphenol flavonoid enesakhiwo esikhethekile. Yakhiwa ngokuxhuma ama-epicatechin amabili. Ingakhishwa ekudleni okunjengamakinati, ama-apula, amagilebhisi nokunye. Ucwaningo lwangaphambilini luthole ukuthi ama-proanthocyanidin anemisebenzi yebhayoloji efana ne-antioxidant kanye -eqeda ukuvuvukala, anganciphisa amazinga e-cholesterol, avikele amangqamuzana e-vascular endothelial emonakalweni we-vascular endothelium, ngaleyo ndlela avimbele izifo zenhliziyo nemithambo yegazi, ehlise i-lipids egazini kanye noshukela, futhi asebenzise{6}}imiphumela eqeda isimila, njll{7}}I-OPC ekhishwe{7}}Ocwaningweni olutholile luthole ocwaningweni olubomvu lwe-OPC{7}} ibophezela ngokuqondile futhi ivimbele umsebenzi we-AKT kanye nezindlela zokubonisa ezingezansi, ngaleyo ndlela ivimbele ukwanda, i-metabolism kanye nokukhula kwe-tumor yamangqamuzana omdlavuza wesibindi. Ucwaningo luphinde lwathola ukuthi isebenzisana ne-AKT allosteric inhibitor MK eyaziwayo Efana nokuthi -2206, OPC{16}}B2 ingabophezela kusizinda se-catalytic kanye nesizinda se-PH se-AKT, ngaleyo ndlela ivimbe umsebenzi we-AKT; I-Lys297 kanye ne-Arg86 amasayithi angukhiye wokubophezela kwe-AKT ku-OPC-B2, futhi ukuguqulwa kukhulula -umthelela wesimila we-OPC-B{20}}
Lo msebenzi wokucwaninga uxhaswe yiNational Key Key Research and Development Programme yoMnyango Wezesayensi Nobuchwepheshe, iNational Natural Science Foundation yaseChina, kanye neChinese Academy of Sciences.
