Ukuhlolwa kweseli kwe-Salvia miltiorrhiza tincture kunganqanda izinhlobo eziningi-ezimelana nezidakamizwa.
Ngo-1994, i-World Health Organization yahlukanisa i-Helicobacter pylori njengesigaba I-carcinogenic factor, ngoba idlala indima ehamba phambili ekuthuthukiseni umdlavuza wesisu. Indlela yokuqeda lo mbulali wezempilo? Ngo-2017, ithimba lika-Bi Hongkai lenze impumelelo ngokuhlolwa kokuqala -- uSalvia miltiorrhiza.
I-red sage supplement ingenye yemithi yendabuko yaseShayina esetshenziswa kakhulu ukukhuthaza ukujikeleza kwegazi nokususa ukusimama kwegazi eChina. Amafutha ayo-ancibilikayo, okuyinhlanganisela ye-tanshinone, afaka i-tanshinone I, i-dihydrotanshinone, i-tanshinone ⅡA, i-cryptotanshinone namanye ama-monomer angaphezu kuka-30. Izinhlanganisela zezimpande ze-Salvia miltiorrhiza zinemiphumela ehlukahlukene yezekhemisi, efana-nomdlavuza,-ibhaktheriya elihle, elilwa-nokuvuvukala, i-estrogen{7}}njengomsebenzi nokuvikelwa kwenhliziyo nemithambo yegazi, kodwa i-anti{8}}Helicobacter pylori ayizange ibikwe.
Ngaphambilini, sihlole ama-monomers emithi yendabuko yamaShayina angaphezu kuka-1000 ezingeni leseli, futhi ekugcineni sanquma ukuthi i-dihydrotanshinone I monomer ku-Dan shen extract ibe nomthelela ongcono kakhulu wokubulala ku-Helicobacter pylori. Ekuhloleni amaseli, i-dihydrotanshinone I ivimbele ukukhula kwezinhlobo ezimbalwa ze-H. pylori, okuhlanganisa ama-antibiotic-azwelayo kanye nezinhlobo eziningi zezidakamizwa-ezimelana nezidakamizwa, ekugxiliseni okusuka ku-0.125 ug/mL kuya ku-0.5 ug/mL. I-Dihydrotanshinone Ngiphinde ngaba nomphumela omuhle wokubulala ku-Helicobacter pylori ku-biofilm, futhi enqubweni yokudlula eqhubekayo, i-Helicobacter pylori ayizange ihlakulele ukumelana ne-Dihydrotanshinone I.
Isimanga esikhulu ukuthi lapho ngibulala i-Helicobacter pylori, i-dihydrotanshinone angikwazi nje ukubhubhisa i-biofilm, kodwa futhi ngibulale amabhaktheriya axhunywe ku-biofilm, edlala indima "yokusiphula" i-Helicobacter pylori.
Ukukhishwa kwe-sage ebomvu akukwazi ukusetshenziswa ngokuqondile ukuvimbela ukutheleleka kwe-Helicobacter pylori, futhi i-monomer yayo, i-dihydrotanshinone I, iseyindlela ende yokwenza umuthi otholakala emtholampilo. Esinyathelweni esilandelayo, kuzocutshungulwa indlela yokusebenza ye-dihydrotanshinone, kanye nesayensi yezemithi kanye ne-toxicology ye-anti{1}}Helicobacter pylori resistance of dihydrotanshinone I izothuthukiswa.
