Ikhasi lewolintshi yikhasi elomile, elivuthiwe leCitrus reticulata Blanco kanye nezinhlobo zayo zomndeni wakwaRutaceae. Ngokwemvelaphi nezinhlobonhlobo ezahlukahlukene, izinto zokwelapha ze-tangerine peel zihlukaniswe "i-tangerine peel" kanye "ne-guang tangerine peel". Ikhasi le-tangerine lesiCantonese libhekisela emakhasini e-tangerine akhiqizwa ikakhulukazi e-Xinhui, e-Guangdong. Icutshungulwa kusukela kukhasi elivuthiwe le-Citrus reticulata 'Chachi', isilimo se-tangerine. Yizinga eliphezulu lezinto zokwelapha ze-tangerine peel. Kusukela ezikhathini zasendulo, ikhasi le-tangerine lesiCantonese lingelokuqala Kwamagugu Amathathu aseGuangdong. Ukuze kuhlolwe indlela ye-"Chen Jiu Zheliang" yekhasi le-tangerine lesiCantonese, ithimba likaProfesa Wu Hong lasebenzisa i-ultra{{6}high performance liquid chromatography{7}}triple quadrupole mass spectrometry (UPLC{8}}MS/MS), kuhlanganiswe nezindlela zokuhlaziya i-metabolomic ukuze lihlaziye izindlela ezihlukene zokuguga. Iminyaka (iminyaka engu-0-4 kanye ne-29) ye-flavonoid emakhasini we-tangerine yafundwa (ngezansi).
Umfanekiso 1 Amasampula e-Cantonese tangerine peel (iminyaka engu-0, 1, 2, 3, 4, 29)
Imiphumela ibonise ukuthi isamba sama-metabolites e-flavonoid (flavonoid metabolites) angu-219 atholiwe, okuhlanganisa i-5,7,3',4',5'-pentamethoxydihydroflavonoids, 2'{8}}hydroxy{15}}3,4,5, 3'4', 3', 4',5', {6}pentamethoxydihydroflavonoids, 2'{8}}hydroxy{15}}3,4,5, 3'4',4}firstdetect{3}xydthomethome{3}ye-firstdetect{3}xythomethome{3}ye-1 isikhathi eside ku-tangerine peel. Ngokusho kokuhlaziywa kweqoqo le-metabolite, ikhasi le-tangerine elomisiwe elineminyaka engu-0, 1, 2 ubudala laliyingxenye eyodwa, kanti amakhasi e-tangerine omisiwe aneminyaka engu-3, 4, 29 ayekwesinye isigaba. Imiphumela yokuhlaziywa komthamo ibonise ukuthi okuqukethwe kwama-flavonoid glycosides angu-4 ohlotsheni lwangaphambili lwekhasi le-tangerine kwakuphakeme kunohlobo lwakamuva, futhi okuqukethwe kwama-polymethoxyflavonoid angu-15 kwakungaphezulu kwalokho kohlobo lwakamuva. Ikhasi le-tangerine elingaguge (iminyaka engu-0) laqhathaniswa namanye amaqembu amahlanu ama-tangerine peels (iminyaka engu-1, 2, 3, 4, kanye nengu-29) aneminyaka ehlukene yokuguga, futhi kwatholakala ukuthi i-poplaraxanthin, i-apigenin, 2'{36}} I-Hydroxyisoflavones, i-luteolin, i-6- i-quercetin-O-i-acetylhexoside ne-apigenin-7-O-[ -D-glucuronide (1→ 2)-O- -D-glucuronide) Lawa ma-flavonoid ayisishiyagalombili angasetshenziswa njengengxenye yesikhumba eyingqopha kwesikhumba esingagugi.
I-APC ibonise ukuthi umsebenzi ophelele we-antioxidant wekhasi le-tangerine eminyakeni emi-3 no-4 wawunamandla kunalowo weminye iminyaka. Kubonisa ukuthi ukwakheka kwekhasi le-tangerine kushintshile ngekhwalithi kanye nobuningi ngemuva kokuguga iminyaka engaphezu kwemithathu, futhi ukuguga kukhuthaza ngokuqondile ukwanda kwezinhlobo nokuqukethwe kwe-polymethoxyflavonoids ku-tangerine peel. Ama-Polymethoxyflavones awagcini nje ngokuba nomsebenzi omuhle wokulwa ne-antioxidant, kodwa futhi anciphisa izifo ze-metabolic ezifana ne-hypertriglyceridemia, isibindi esinamafutha, nokumelana ne-insulin ngokulawula amagciwane amathumbu kanye ne-amino acid metabolism. Ukukhula, ukufakwa kwe-tumor cell apoptosis nezinye izindlela kudlala indima ekwelapheni umdlavuza.
Nokho, ngokufakwa kwamamolekyuli kwama-flavonoid angu-8 abalulekile ecwecweni le-tangerine eline-coronavirus entsha (i-SARS-i-CoV-2) i-Spike protein, i-SARS-i-CoV-2 RNA polymerase nama-protease abalulekile (3CLpro, PLpro), kutholakale ukuthi kukhona ama-flavonoid athile ecwecweni le-tangerine. Ukuhlangana okubophezelayo kwama-flavonoid kumaprotheni amane abalulekile asebenzayo e-SARS-CoV-2 kwakungcono kakhulu kunomuthi wokulawula omuhle. Imiphumela ibonise ukuthi okuqukethwe kwezingxenye ezingase zibe khona ngokumelene ne-2019-nCoV e-Canton tangerine peel new peel (iminyaka engu-0 ubudala) yayiphezulu kakhulu kunaleyo yekhasi elidala elidala.
Ngokusekelwe kulokhu, abacwaningi baphakamisa ukuthi uma usebenzisa ikhasi le-tangerine eline-polymethoxyflavonoids njengesithako esisebenzayo, kutuswa ukusebenzisa ikhasi le-tangerine iminyaka engaphezu kwemi-3. Uma ithuthukiswa futhi isetshenziswa njenge-antioxidant, kungcono ukuguga iminyaka engu-3-4 yekhasi le-tangerine elomisiwe. Uma isetshenziswa{6}njengomuthi we-coronavirus, kungcono ukusebenzisa izikhumba ezintsha ezingakagugi. Imiphumela yalolu cwaningo ihlinzeka ngedatha yesayensi yokulawulwa kwekhwalithi, ukuhlolwa kanye nokusetshenziswa okunengqondo kwezinto zokwelapha zekhasi le-tangerine elidala, futhi ihlinzeka ngedatha eyisisekelo yokuhlaziywa okujulile kokulawulwa kwe-metabolic yezingxenye zokwelapha zekhasi le-tangerine.
